What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
FGAM → 5-aminoimidazole ribonucleotide (AIR)
Converts Formylglycinamidine ribonucleotide (FGAM) into 5-Aminoimidazole ribonucleotide (AIR)
› Notes
AIR synthetase catalyzes ATP-dependent ring closure: FGAM + ATP → AIR + ADP + Pi. This irreversible cyclization forms the imidazole portion of the purine nucleus.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).
Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03
open access unreviewed -
2
The Complex Relation of Branched-Chain Amino Acids and Inflammation in the Obesity and Diabetes Context.
Starling-Soares B, Coelho MM, Campolina BG, Duarte CK, Maioli TU. · 2026-01-22
cited 2× open access unreviewed -
3
A mathematical model of folate-mediated one-carbon metabolism in Down syndrome.
Piovesan A, Poluzzi D, Ramacieri G, Locatelli C, Antonaros F, Vione B, Caracausi M, Pelleri MC, Marchetti L. · 2026-06-26
unreviewed -
4
Genetic Interruption of PD-1/PD-L1 as an Alternative Means for Immune Checkpoint Blockade in Cancer: A Review.
Li D, Lu J, Li Q, Deng H, Tan S. · 2026-06-18
open access unreviewed - 5
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6
Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis.
Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanj… · 2026-06-10
open access unreviewed -
7
Non-inferiority testing for the odds ratio in two independent binomial proportions using the method of variance estimates recovery.
Chen H, Wang D, Wu Y, Huang S, Huang J, Liu H, Chen Y, Chen C. · 2026-06-05
unreviewed -
8
Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.
Terra C, Terrier O, Le Gouellec A. · 2026-06-02
open access unreviewed -
9
Transcriptome-constrained genome-scale metabolic modeling reveals central carbon and amino acid metabolic reprogramming underlying colistin-sulbactam synergy in <i>Acinetobacter baumannii</i>.
Bian X, Zhu Y, Liu X, Li X, Li W, Zhao J, Li J, Zhang J. · 2026-05-05
open access unreviewed -
10
A Bayesian Framework to Account for Misclassification Error and Uncertainty in the Estimation of Abortion Prevalence.
Pejchinovska M, Alexander M. · 2026-05-05
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.