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unreviewed

Mevalonate-5-pyrophosphate decarboxylase

2 reactions · 1 pathways

Cofactors used

ATP Pi

What it does, reaction by reaction

2 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 6 Irreversible/directional

5-Pyrophosphomevalonate + ATP → 3-phospho-5-pyrophosphomevalonate + ADP

Converts 5-Pyrophosphomevalonate ATP into 3-Phospho-5-pyrophosphomevalonate ADP

› Notes

Mevalonate-5-pyrophosphate decarboxylase phosphorylates the C3 hydroxyl. ATP is consumed; this preparatory phosphorylation enables the subsequent decarboxylation.

step 7 Irreversible/directional

3-Phospho-5-pyrophosphomevalonate → isopentenyl pyrophosphate (IPP) + CO2 + Pi

Converts 3-Phospho-5-pyrophosphomevalonate into Isopentenyl pyrophosphate (IPP) CO2 Pi

› Notes

The same mevalonate-5-pyrophosphate decarboxylase catalyzes decarboxylation/elimination to form activated C5 isoprene unit IPP. Together, steps 4–7 consume three ATP per IPP.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    The clinical utility of intraoperative blink reflex monitoring and its synergistic value with lateral spreading response monitoring in predicting postoperative outcomes in patients with hemifacial spasm following microvascular decompression.

    Yang J, Yang X, Liu J, Li K, Shi J, Liang Y, Liang S, Liu H, Qiao H, Fan X. · 2026-07-13

    unreviewed
  2. 2
    Epidemiology and containment of the first Marburg virus disease outbreak in Ethiopia in 2025: A retrospective descriptive study.

    Hassen HM, Ibrahim AF. · 2026-07-01

    unreviewed
  3. 3
    <i>De novo</i> production of (-)-limonene, (-)-carveol and (-)-carvone via engineering <i>Rhodotorula toruloides</i>.

    Dong Y, Cui S, Du B, Zhang X, Hou J, Lin X, Qin Y, Wang X, Yang X. · 2026-06-13

    open access unreviewed
  4. 4
    Rapid assessment of local disease control measures against the Marburg virus outbreak in Ethiopia in late 2025.

    Wu Q, Guo Z, Yuan Z, Ali ST, Wang K, Ryu S, Cao L, Sun S, Chong MKC, Musa SS, He D, Zhao S, Feng Z, Habib AG,… · 2026-06-09

    open access unreviewed
  5. 5
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  6. 6
    Metadherin: A pivotal oncogene and therapeutic target in head and neck cancer - a systematic review.

    Lee S, Porntaveetus T, Hong SD, Cho SD. · 2026-06-03

    open access unreviewed
  7. 7
    Systems engineering of <i>Escherichia coli</i> for high-level hydroxytyrosol production.

    Zuo J, Zhang S, Huang W, Liu J, Gao C, Hu GP, Song W, Li X, Wei W, Wu J, Liu L, Liu K, Xu N. · 2026-06-01

    open access unreviewed
  8. 8
    TFPI2 in tumor metastasis: a double-edged sword with clinical implications.

    Guo Z, Luo Y, Wen J, Jiang Y, Kuang Q, Ma Q, Zheng C, Li X, You F, Fu X. · 2026-05-30

    open access unreviewed
  9. 9
    Biological-chemical method for synthesizing <i>p</i>-menthane-3,8-diol.

    Zuo X, Zhang H, Zhang Z, Ma Y, Zhang C, Lu W. · 2026-05-12

    open access unreviewed
  10. 10
    Integrated radiopathomics nomogram for predicting angiogenic microvascular patterns in NSCLC: a dual-center validation study.

    Wang R, Wang L, Wang X, Quan S, E L, Du J. · 2026-04-17

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.