What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
5-Pyrophosphomevalonate + ATP → 3-phospho-5-pyrophosphomevalonate + ADP
Converts 5-Pyrophosphomevalonate ATP into 3-Phospho-5-pyrophosphomevalonate ADP
› Notes
Mevalonate-5-pyrophosphate decarboxylase phosphorylates the C3 hydroxyl. ATP is consumed; this preparatory phosphorylation enables the subsequent decarboxylation.
3-Phospho-5-pyrophosphomevalonate → isopentenyl pyrophosphate (IPP) + CO2 + Pi
Converts 3-Phospho-5-pyrophosphomevalonate into Isopentenyl pyrophosphate (IPP) CO2 Pi
› Notes
The same mevalonate-5-pyrophosphate decarboxylase catalyzes decarboxylation/elimination to form activated C5 isoprene unit IPP. Together, steps 4–7 consume three ATP per IPP.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
System reconstruction of <i>Bacillus licheniformis</i> for efficient expression of alkaline protease.
Zhang Q, Zhang M, Zhu Z, Ma H, Mo F, Lei J, He S, Liao Y, Yan S, Cai D, Chen S. · 2026-08-01
open access unreviewed -
2
Reduced-parameter ultrasound electrical impedance spectroscopy for characterization of piezoelectric transducers and polymer materials.
Acevedo-Espinosa JF, D'Amato FOS, Vermelho MVD, Branco AKXB, Carneiro AAO, Baudoin M, Ealo JL, Silva GT. · 2026-09-03
unreviewed -
3
Plant essential oils against woody plant fungal pathogens: chemical composition, antifungal mechanisms, and translational challenges.
Alizadeh M. · 2026-09-18
open access unreviewed -
4
Re-emerging Marburg virus disease in Africa: spillover ecology, geographic expansion, and surveillance vulnerabilities.
Tibbo M, Barigye R, Ameni G. · 2026-09-11
open access unreviewed -
5
A dual-modality workflow for quantifying microvascular structure in human temporal lobe epilepsy.
Xu Z, Tempeli V, Hartjes S, Kotenko A, Hoogland G, Haeren RHL, Schijns OEMG, van Lanen RHGJ, van Zandvoort MA… · 2026-08-21
open access unreviewed -
6
Documented preoperative depression is not significantly associated with pain outcomes following microvascular decompression for Type 1 trigeminal neuralgia.
Carnovale BJ, Hartung P, Bhatia S, Gopakumar A, Ghanta RK, Lee D, McKay W, Pathakamuri A, Zenonos GA. · 2026-08-21
unreviewed -
7
Sequence cluster and distal-site engineering of Fdc for efficient isobutene biosynthesis.
Feng T, Cao X, Yang L, Huang H, Feng Y, Fang Y, Xue S. · 2026-08-16
unreviewed -
8
Liposomal Gel for enhancing topical efficacy of timolol maleate against proliferating superficial infantile hemangiomas.
Hang X, Jin T, Hua J, Zhang X, Song W. · 2026-07-26
open access unreviewed -
9
Enhanced oxalate decarboxylase biomanufacturing via multi-level optimization and integrated life cycle assessment.
Hou N, Guo H, Wang T, Li D, Li L, Zhao X. · 2026-07-17
unreviewed -
10
The clinical utility of intraoperative blink reflex monitoring and its synergistic value with lateral spreading response monitoring in predicting postoperative outcomes in patients with hemifacial spasm following microvascular decompression.
Yang J, Yang X, Liu J, Li K, Shi J, Liang Y, Liang S, Liu H, Qiao H, Fan X. · 2026-07-13
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.