unreviewed

Mevalonate-5-pyrophosphate decarboxylase

2 reactions · 1 pathways

Cofactors used

ATP Pi

What it does, reaction by reaction

2 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 6 Irreversible/directional

5-Pyrophosphomevalonate + ATP → 3-phospho-5-pyrophosphomevalonate + ADP

Converts 5-Pyrophosphomevalonate ATP into 3-Phospho-5-pyrophosphomevalonate ADP

› Notes

Mevalonate-5-pyrophosphate decarboxylase phosphorylates the C3 hydroxyl. ATP is consumed; this preparatory phosphorylation enables the subsequent decarboxylation.

step 7 Irreversible/directional

3-Phospho-5-pyrophosphomevalonate → isopentenyl pyrophosphate (IPP) + CO2 + Pi

Converts 3-Phospho-5-pyrophosphomevalonate into Isopentenyl pyrophosphate (IPP) CO2 Pi

› Notes

The same mevalonate-5-pyrophosphate decarboxylase catalyzes decarboxylation/elimination to form activated C5 isoprene unit IPP. Together, steps 4–7 consume three ATP per IPP.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

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