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unreviewed

AICAR transformylase (ATIC)

2 reactions · 2 pathways

Cofactors used

THF (folate) · B9 (Folate)

What it does, reaction by reaction

2 reactions

One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 8 Irreversible/directional

10-Formyl-THF + AICAR → formyl-AICAR + THF

Converts 10-Formyl-THF AICAR into FAICAR Tetrahydrofolate (THF)

› Notes

AICAR transformylase (ATIC) donates the second formyl group required for inosine monophosphate synthesis. This reaction is followed by cyclization to IMP by the IMP cyclohydrolase activity of ATIC.

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 10 Irreversible/directional

AICAR → 5-formamidoimidazole-4-carboxamide ribonucleotide (FAICAR)

Converts AICAR into FAICAR

› Notes

AICAR transformylase catalyzes AICAR + 10-formyl-THF → FAICAR + THF. The donated formyl carbon becomes C2 of the purine ring.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.

    Prasadani M, Jaakson H, Karis P, Muhandiram S, Henno M, Kuusik S, Ling K, Rajapaksha H, Ots M, Andronowska A,… · 2026-05-01

    cited 1× open access unreviewed
  2. 2
    ThermoTargetMiner as a proteome integral solubility alteration target database for prospective drugs against lung cancer.

    Lyu H, Gharibi H, Sokolova B, Varli M, Voiland A, Nilsson B, Meng Z, Gaetani M, Saei AA, Zubarev RA. · 2026-10-02

    open access unreviewed
  3. 3
    HSP60 and HSP10 depletion provoke distinct biological responses.

    Ben-David H, Gabbay S, Sued-Hendrickson S, Cohen L, Levin L, Tickotsky Moskovitz N, Abramovich I, Dror S, Bro… · 2026-10-01

    open access unreviewed
  4. 4
    ISoP MENA Chapter: Strategic Development and Future Directions Following a Decade of Strengthening Pharmacovigilance in the Middle East and North Africa.

    Rostom H, Elhawary MA, Alkhakany M, Younus MM, Alshammari T, Villalobos F, Aimer O. · 2026-09-02

    unreviewed
  5. 5
    SpaReg: sparsity-based 3D reconstruction of tissue microenvironments at native resolution across morphological and spatial molecular modalities

    · 2026-09-29

    open access unreviewed
  6. 6
    Interactions between epistasis and pleiotropy in generic models of complex traits

    · 2026-09-30

    open access unreviewed
  7. 7
    Mitophagy-related gene signatures predict prognosis and therapeutic response in hepatocellular carcinoma.

    Luo H, Yang Y, Wen J, Hou Y. · 2026-09-30

    unreviewed
  8. 8
    Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis.

    Hall B, Ebrahim YM, Sharpe JL, Makhija S, Ellis BCS, Wong KE, Walker H, Yagüe-Capilla M, Timmons HO, Bradley … · 2026-09-16

    open access unreviewed
  9. 9
    In-silico personalized protein-protein interaction networks prioritize candidate compounds for glioblastoma.

    Siminea N, Popescu VB, Păun M, Petre I, Păun A. · 2026-09-22

    open access unreviewed
  10. 10
    Phenotype-Specific Pharmacogenetic Patterns of Methotrexate Neurotoxicity in Pediatric Acute Lymphoblastic Leukemia.

    Gómez-Román J, Restrepo JC, González LM, González-Rodríguez L, Lacombe-Antoneli Á, Gutiérrez-Martín Y, de la … · 2026-09-05

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.