Skip to content
MS
Sign in
unreviewed

AICAR transformylase (ATIC)

2 reactions · 2 pathways

Cofactors used

THF (folate) · B9 (Folate)

What it does, reaction by reaction

2 reactions

One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 8 Irreversible/directional

10-Formyl-THF + AICAR → formyl-AICAR + THF

Converts 10-Formyl-THF AICAR into FAICAR Tetrahydrofolate (THF)

› Notes

AICAR transformylase (ATIC) donates the second formyl group required for inosine monophosphate synthesis. This reaction is followed by cyclization to IMP by the IMP cyclohydrolase activity of ATIC.

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 10 Irreversible/directional

AICAR → 5-formamidoimidazole-4-carboxamide ribonucleotide (FAICAR)

Converts AICAR into FAICAR

› Notes

AICAR transformylase catalyzes AICAR + 10-formyl-THF → FAICAR + THF. The donated formyl carbon becomes C2 of the purine ring.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

  1. 1
    Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.

    Prasadani M, Jaakson H, Karis P, Muhandiram S, Henno M, Kuusik S, Ling K, Rajapaksha H, Ots M, Andronowska A,… · 2026-05-01

    open access unreviewed
  2. 2
    Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).

    Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03

    open access unreviewed
  3. 3
    The Use of Extracorporeal Organ Support Therapies for Acute Kidney Injury in Cancer Patients.

    Atić A, Forni L, Premužić V. · 2026-08-03

    unreviewed
  4. 4
    Exploratory Machine Learning and Omics Integration in the Search for Biomarkers of Papillary Thyroid Cancer.

    Sanches PHG, de Melo NC, de Oliveira DC, de Carvalho LM. · 2026-06-25

    unreviewed
  5. 5
    Combined Analysis of Bulk and Single-Cell Transcriptomic Data Reveals Dormancy-Associated Genes in Colorectal Cancer

    · 2026-06-01

    open access unreviewed
  6. 6
    5Targeting Pin1 in cholangiocarcinoma tumor and stromal cells using siRNA therapeutics

    · 2026-06-01

    open access unreviewed
  7. 7
    When Perceptions of Social Desirability Differ: Implications for the Multidimensional Nominal Response Model of Faking.

    Kleinbub JD, Seitz T. · 2026-06-19

    open access unreviewed
  8. 8
    TRP channels as critical pathways in temperature-induced asthma.

    Deng S, Zhou X, Wang Z, He J, Gao Q, Wang L. · 2026-06-12

    open access unreviewed
  9. 9
    Theory of hybrid defects, with coupled orientational order parameters, on flat and curved surfaces.

    Paik L, Selinger JV. · 2026-06-23

    unreviewed
  10. 10
    Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis.

    Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanj… · 2026-06-10

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.