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unreviewed

Lipoprotein lipase (LPL)

2 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. LPL or apoC-II deficiency: familial chylomicronaemia (type I), pancreatitis

What it does, reaction by reaction

2 reactions

Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium

step 5 Irreversible/directional

Chylomicron TAG + H2O → fatty acids + glycerol

Converts Chylomicron TAG H2O into Fatty acid Glycerol

› Notes

Endothelial LPL, activated by apoC-II and anchored by GPIHBP1, hydrolyzes core TAG. Insulin increases LPL activity in adipose tissue in the fed state, whereas cardiac/skeletal muscle LPL favors fatty-acid uptake according to local energy demand. Released fatty acids enter adipocytes for storage or muscle for oxidation; glycerol returns to liver.

step 10 Irreversible/directional

VLDL TAG + H2O → fatty acids + glycerol; VLDL → IDL

Converts VLDL TAG H2O into Fatty acid Glycerol VLDL

› Notes

LPL, activated by apoC-II, removes much of the VLDL TAG in capillary beds. ApoC-II is returned to HDL, and the particle becomes an intermediate-density lipoprotein (IDL; VLDL remnant) enriched in cholesteryl esters and retaining apoB-100 and apoE.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL)

Accelerated by

ApoC-II; GPIHBP1-mediated endothelial presentation; ANGPTL8 in the fed state favors adipose LPL

Inhibited by

ApoC-III; ANGPTL3/ANGPTL4 (tissue/context dependent)

Hormonal control

Insulin increases adipose LPL after feeding; fasting shifts relative LPL activity toward oxidative tissues

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Predicting longevity-related traits in Swiss low-input and organic dairy cows from herdbook data of first versus second lactation.

    Bieber A, Hinrichs D, Moser FN, Maeschli A, Lora I, Cozzi G, Leiber F. · 2026-05-19

    unreviewed
  2. 2
    Effects of dietary nano-selenium and lysophospholipid supplementation on sperm quality and testicular histomorphometry in Moghani ram.

    Aghazadeh L, Mirzaei Aghjeh-Gheshlagh F, Jahani-Azizabadi H, Navid-Shad B, Kalantari-Hesari A, Staji H. · 2026-06-11

    unreviewed
  3. 3
    The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.

    Stephenson GS, Fleifel D, Cook JG, Laederach A, Ramos SBV. · 2026-06-21

    open access unreviewed
  4. 4
    Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.

    Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M. · 2026-06-02

    open access unreviewed
  5. 5
    Combining bioinformatics and machine learning to analyze and validate sepsis-related cell senescence genes and potential drugs.

    Pei S, Li D, Yu X, Huang X, Liu J, Song Y, Zhu L, Cui J, Cui Y, Xie K. · 2026-05-31

    open access unreviewed
  6. 6
    Magnetic nanohydroxyapatite-peptide silk fibroin hydrogel induces osteogenesis in canine periodontal ligament stem cells revealed by proteomic analysis.

    Purbantoro SD, Scatena M, Taephatthanasagon T, Rodprasert W, Somparn P, Nanthawong S, Makjaroen J, Jantaratan… · 2026-05-16

    open access unreviewed
  7. 7
    Triglyceride deposit cardiomyovasculopathy as a predictor of vascular failure after coronary intervention in patients with hemodialysis: a preliminary analysis.

    Fujimoto M, Nakano Y, Hirano KI, Onishi T, Ando H, Ohashi H, Satake A, Waseda K, Takahashi H, Amano T. · 2026-04-22

    open access unreviewed
  8. 8
    <i>Valeriana</i> species and insomnia: multi-organ mechanisms and translational perspectives.

    Yang S, Zhang H, Chen L, Zhang Z, Huang L, Wang W, Lu W, Wang Y, Wu S, Hu Z, Wang S, Chen R, Liang F. · 2026-04-17

    open access unreviewed
  9. 9
    The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production.

    Gautam A, Zhong L, Ogire E, Bodoirat S, Riedmiller I, Sander WJ, Boson B, Gandhi A, Burlaud-Gaillard J, Amira… · 2026-03-30

    open access unreviewed
  10. 10
    Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.

    Samulėnaitė S, Rodriguez Parkitna J, Baltriukienė D, Martín-García E, Maldonado R, Burokas A. · 2026-03-29

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.