Lactate dehydrogenase (LDH)
Cofactors used
Clinical / pharmacological. Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
What it does, reaction by reaction
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
Pyruvate + NADH + H+ ⇌ lactate + NAD+
Converts Pyruvate NADH H+ into Lactate NAD+
› Notes
Required cofactor: NADH/NAD+. This reversible reaction is the defining fermentation step; it produces no additional ATP but is indispensable for maintaining the NAD+ required by glyceraldehyde-3-phosphate dehydrogenase when cytosolic NADH cannot be reoxidized sufficiently through mitochondrial shuttles and the ETC.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Anaerobic Glycolysis / Lactic Acid Fermentation
Listed there as: Lactate dehydrogenase
Pyruvate and NADH availability; high cytosolic NADH/NAD+ ratio favors lactate formation
Product/thermodynamic limitation by high lactate and NAD+; no primary allosteric inhibitor of central control
No dominant acute direct hormonal switch; hormonal changes in glycolytic flux and perfusion indirectly affect lactate production
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Endoscopic Visualization of a Jejuno-Colonic Fistula in a Case of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma.
Ota K, Matsuno Y, Taniguchi Y, Imazu N, Kawatoko S, Ihara Y, Nagasue T, Kawasaki K, Moriyama T, Umeno J. · 2026-06-15
open access unreviewed -
2
A bioactivity-enhanced thermosensitive amnion-derived hydrogel with sustained IGF-1 release: A multitargeted and efficient strategy for corneal injury repair.
Xie M, Li A, Sun X, Liu J, Wei Y, Yang H, Chen S, Zhong X, Quan D, Guan X, Tian L, Jie Y. · 2026-09-16
open access unreviewed -
3
Functionalized biomaterial platforms for interventional embolization therapy of hepatocellular carcinoma.
Zheng N, Tang Z, Yang G, Deng L, Zhao Q, Zhao Y, Zhang J, Wang X, Chai Y, Chen Y, Wu Y, Fu Y, Liu S, Li J, Lu… · 2026-09-08
open access unreviewed -
4
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
5
Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia-reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade.
Zhao H, Zhao J, Zhou D, Lei Y, Liu Z, Chen J, Hu P, Xu X, Xie H, Wei Q. · 2025-12-24
open access unreviewed -
6
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
7
A bioinspired long-acting chlorhexidine-eluting super-hydrophilic coating on vascular catheters prevents thrombosis and biofouling.
Wang C, Liu Y, Li M, Fu Y, Bai N, Rui T, Gu R, Yang C, Yang Z, Xu B. · 2026-08-26
open access unreviewed -
8
Tissue-derived extracellular matrix hydrogels instruct epigenetic adaptation in metastatic colonization.
Yoon H, Kim D, Jeong HJ, Han H, Kim SJ, Jang J, Jung DB, Myung SJ, Yu CS, Song IH, Choi JH, Corces MR, Kwon T… · 2026-08-26
open access unreviewed -
9
Trojan horse-inspired vaccine-like nanoparticle with enhanced lubrication and active-passive synergistic anti-inflammation for post-traumatic osteoarthritis treatment.
Yang Y, Ren J, Sun G, Huang K, Zhao X, Poliakov A, Wang Y, Zhang H. · 2026-08-12
open access unreviewed -
10
Ultrasound-induced cascade nanozyme catalysis for enhanced tumor cell pyroptosis and systemic anti-tumor immunity.
Qin S, Zhao M, Gao W, Zhou Z, Hu Y, Zhang J, Xu J. · 2026-07-27
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.