Lactate dehydrogenase (LDH)
Cofactors used
Clinical / pharmacological. Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
What it does, reaction by reaction
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
Pyruvate + NADH + H+ ⇌ lactate + NAD+
Converts Pyruvate NADH H+ into Lactate NAD+
› Notes
Required cofactor: NADH/NAD+. This reversible reaction is the defining fermentation step; it produces no additional ATP but is indispensable for maintaining the NAD+ required by glyceraldehyde-3-phosphate dehydrogenase when cytosolic NADH cannot be reoxidized sufficiently through mitochondrial shuttles and the ETC.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Anaerobic Glycolysis / Lactic Acid Fermentation
Listed there as: Lactate dehydrogenase
Pyruvate and NADH availability; high cytosolic NADH/NAD+ ratio favors lactate formation
Product/thermodynamic limitation by high lactate and NAD+; no primary allosteric inhibitor of central control
No dominant acute direct hormonal switch; hormonal changes in glycolytic flux and perfusion indirectly affect lactate production
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Endoscopic Visualization of a Jejuno-Colonic Fistula in a Case of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma.
Ota K, Matsuno Y, Taniguchi Y, Imazu N, Kawatoko S, Ihara Y, Nagasue T, Kawasaki K, Moriyama T, Umeno J. · 2026-06-15
open access unreviewed -
2
Redox-mediated mitochondrial collapse drives intrinsic apoptotic signaling in ELT3 cells response to apigenin.
Sutjarit S, Setthawongsin C, Sakulthaew C, Meekhanon N, Ochiai K. · 2026-07-20
unreviewed -
3
Trichodermin exhibits potent anti-glioblastoma activity by inducing cell cycle arrest and apoptosis, suppressing invasion, and enhancing temozolomide efficacy.
Tsai HP, Lee TH, Lin HL, Lin TW, Chang WH, Lin CJ. · 2026-07-20
unreviewed -
4
Association of LDH-derived biochemical ratios with severe pre-eclampsia: a multicenter retrospective cohort study.
Geyik Bayman M, Türen Demir E, Kılıç O, Metin ÜS, Kulhan NG, Doğru Ş, Günenç O, Esenkaya Ü, Büyükeren M. · 2026-07-16
unreviewed -
5
Clinical characteristics and prognosis of peritoneal dialysis-associated peritonitis caused by non-fermenting Gram-negative bacteria: a single-center retrospective analysis.
Yan H, He W, Yu D, Tong M, Ni J, Yu J. · 2026-06-24
open access unreviewed -
6
An mRNA-LNP vaccine expressing TP0435 provides protective immunity in rabbits against <i>Treponema pallidum</i> challenge.
Lu Z, Lu Y, Liu D, Du F, Wu Q, Liao G, Wu Y, Zhang RL, Zhou J, Wang QQ. · 2026-06-21
open access unreviewed -
7
Inhibition of Aryl hydrocarbon receptor Interleukin-22 signaling and worsening of intestinal inflammation by <i>Sutterella</i> species.
Dupraz L, Orianne G, Da Costa G, Gauthier R, Blondeau A, Boinet M, Farfar A, Creusot L, Magniez A, Dubois L, … · 2026-06-21
open access unreviewed -
8
Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review.
Kamal AI, Doppalapudi H, Ho T, Vilayet S, Pasham V, Budisavljevic M, Achanti A. · 2026-06-17
open access unreviewed -
9
The IL-17A/Neutrophil axis plays a critical role in lethal infection induced by an emerging ultra-virulent <i>Streptococcus suis</i> serotype 5 strain.
Chen G, Zhang X, Wang J, Du P, Sun H, Zheng H, Xu J. · 2026-06-21
open access unreviewed -
10
Gut microbial markers of immunotherapy response in melanoma: a cross-cohort analysis including the first Russian dataset.
Strokach A, Zakharevich N, Aginova V, Grigoryevskaya Z, Petukhova I, Bagirova N, Romanov M, Dyachkova M, Moro… · 2026-06-15
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.