Isovaleryl-CoA dehydrogenase
Cofactors used
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Leucine-derived isovaleryl-CoA → 3-methylcrotonyl-CoA → 3-methylglutaconyl-CoA → HMG-CoA → acetoacetate + acetyl-CoA
Converts Leucine-derived isovaleryl-CoA into 3-Methylcrotonyl-CoA
› Notes
Isovaleryl-CoA dehydrogenase uses FAD, 3-methylcrotonyl-CoA carboxylase uses biotin, ATP, and bicarbonate, and downstream hydratase/lyase reactions form the final ketogenic products. Thus leucine is exclusively ketogenic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.
Europe PMC · ten most recent, newest first