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rate-limiting unreviewed

IMP dehydrogenase (IMPDH)

1 reactions · 1 pathways

Cofactors used

H2O NAD+ · B3 (Niacin) NADH · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 14 Irreversible/directional

IMP → xanthosine monophosphate (XMP)

Converts IMP into Xanthosine monophosphate (XMP)

› Notes

IMP dehydrogenase (IMPDH) catalyzes IMP + NAD+ + H2O → XMP + NADH + H+. This oxidation establishes the 2-keto group needed for subsequent amination and is the committed, regulatory step of the GMP branch.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP)

Listed there as: IMP dehydrogenase

Accelerated by

IMP; increased AMP demand can favor GMP synthesis through reciprocal branch control

Inhibited by

GMP and GDP

Hormonal control

Increased expression accompanies lymphocyte activation and cell proliferation; no major direct endocrine allosteric control.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    A guanosine metabolism-bioenergetics intersection drives Parkinson’s disease

    · 2026-08-10

    open access unreviewed
  2. 2
    Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart.

    Rumyantseva A, Tippetts TS, Wilhalm A, Carter W, Moedas M, Rosenberger FA, Moore D, Végvári Á, Hinze Y, Muell… · 2026-08-26

    cited 1× open access unreviewed
  3. 3
    Nucleotide Metabolism in Health and Disease.

    Zhao X, Zeng Y, Xu Y, Rao S, Khouchani M, Soummane H, Li J, Liu R. · 2026-08-12

    open access unreviewed
  4. 4
    Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis.

    Dörfer E, Sadeghi Z, Frick V, Ebel K, Heide A, Niehoff T, Zehner S, Fischer L, Witte CP, Herde M, Möhlmann T. · 2026-08-01

    open access unreviewed
  5. 5
    Gut metaproteomics reveals activated arginine catabolism and impaired arginine biosynthesis in systemic lupus erythematosus.

    Xiong W, Zheng X, Yuan L, Yin L, Tang D, Dai Y, Wang Q. · 2026-07-10

    open access unreviewed
  6. 6
    Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition.

    Zhang J, Song K, Han W, Wang Z, Cao G. · 2026-07-30

    open access unreviewed
  7. 7
    Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons.

    Gu J, Fan C, Xiang S, Yang L, Liu J, Si Y, Zhu B, Sun Y, Ding C, Cao S, Ye J. · 2026-07-07

    open access unreviewed
  8. 8
    Uncovering the potential anti-cancer compounds from Strobilanthes cusia against colorectal cancer through network pharmacology and molecular docking.

    Dhanapal Y, Sridhar D, Khute S, Subash P. · 2026-06-15

    open access unreviewed
  9. 9
    Pharmacogenetics of Mycophenolic Acid in Patients of African Descent: Underrepresentation of African Data.

    Mouton M, Davidson B, Taylor J, Blockman M, Jones E, Freercks R, Mnika K, Dandara C. · 2026-05-01

    open access unreviewed
  10. 10
    Integrated transcriptomic and metabolomic analyses reveal targeting hexokinase 2 disrupts glycolysis and nucleotide metabolism to inhibit NSCLC growth.

    Zhou J, Deng R, Pan L, Zhao Q, Wang Y, Wang Q, Liu Y, Yu Y. · 2026-05-14

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.