What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
FAICAR → IMP
› Notes
IMP cyclohydrolase catalyzes FAICAR → IMP + H2O (net ring closure with dehydration/rearrangement as represented by the enzyme mechanism). This completes the six-membered ring and is effectively irreversible under cellular conditions. IMP contains hypoxanthine and is the branch point for AMP and GMP.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Dynamics of enzyme and metabolic profile of broilers fed black soldier fly (<i>Hermetiailucens</i>) larvae-based diets.
Oladejo OA, Ibiwoye DO, Faniyi AA, Ayoola MO, Oguntunji AO, Ayansina AD, Dahunsi SO. · 2026-05-14
open access unreviewed -
2
Investigation of the effects and underlying mechanisms of adenylate kinase 1 on inosine monophosphate deposition in Beijing-You chickens.
Hou J, Zhang Y, Zhu L, Qi X, Wang X, Lin Z, Xiao L, Long C, Dou J, Xu Y, Sheng X. · 2026-03-23
open access unreviewed -
3
ATIC Promotes LIHC Progression and Serves as an Independent Prognostic Marker: A Pan-cancer Transcriptomic Analysis.
Li H, Zhang W, Zhou X, Wu W, Yao F, Zhong H, Zhan N, Chen J, Zhan Y, Yang X. · 2026-05-11
unreviewed -
4
Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational Insights.
Guzmán-Martín CA, González-Moyotl NJ, Juárez-Vicuña Y, Bojalil R, Martínez-Martínez LA, Arenas-Díaz AL, Martí… · 2026-04-07
open access unreviewed -
5
The effects of chromium yeast on lipid metabolism, antioxidant status, and meat development in broilers under high stocking density.
Han M, Zhang H, Chen Z, Dong Y, Miao Z, Huang C, Xia C, Ning J, Guo Y, Yan L, Li J. · 2026-04-18
open access unreviewed -
6
Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.
Li JY, Zhang XQ, Sheng R. · 2026-04-21
open access unreviewed -
7
Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications.
Fang J, Ling J, Liu X, Wang Y, Huang Y, Cao Z, Zou Y, Xiong H. · 2026-04-14
open access unreviewed -
8
Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma.
Seo Y, Han YD, Bojmar L, Kim KA, Seo Y, Kim TK, Lee S, Kim Y, Choi HB, Lim YH, Kim CH, Sandberg A, Fan C, Lau… · 2026-04-01
open access unreviewed -
9
IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review).
Zhu H, Wang H, Li X, Zhang W, Wang Y, Tan Q, Ying D, Shi Z, Song J. · 2026-02-06
open access unreviewed -
10
The oncogenic control of nucleotide synthesis.
Vidal-Cruchez O, Ben-Sahra I. · 2026-03-26
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.