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unreviewed

IMP cyclohydrolase

1 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 11 Irreversible

FAICAR → IMP

Converts FAICAR into IMP

› Notes

IMP cyclohydrolase catalyzes FAICAR → IMP + H2O (net ring closure with dehydration/rearrangement as represented by the enzyme mechanism). This completes the six-membered ring and is effectively irreversible under cellular conditions. IMP contains hypoxanthine and is the branch point for AMP and GMP.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    The effects of chromium yeast on lipid metabolism, antioxidant status, and meat development in broilers under high stocking density.

    Han M, Zhang H, Chen Z, Dong Y, Miao Z, Huang C, Xia C, Ning J, Guo Y, Yan L, Li J. · 2026-04-18

    cited 1× open access unreviewed
  2. 2
    Proteome of Human Scalp Hair Follicles.

    Hegde A, Srinivasan Y, Chavan MA, Kalsi G. · 2026-08-24

    open access unreviewed
  3. 3
    Acinetobacter guillouiae, a lipolytic strain isolated from sludge capable of partially depolymerising polyethylene terephthalate: genomic, proteomic, and biochemical insights.

    Akhtar N, Najjari A, Magnone A, Yerebakan EC, Bernfur K, Tullberg C, Awan MS, Majeed Z, Grey C, Zhang B, Lina… · 2026-08-26

    open access unreviewed
  4. 4
    MAAMOUL: metabolic network-based discovery of microbiome-metabolome shifts in disease.

    Muller E, Baum S, Borenstein E. · 2026-08-01

    open access unreviewed
  5. 5
    Intrinsic resistance networks shape cefiderocol susceptibility in ST258 <i>Klebsiella pneumoniae</i>.

    Rome KJ, Terlecky AJ, Yen KK, Long T, Bucich MJ, Thom KV, Shashkina E, Chen L, Kreiswirth BN. · 2026-06-18

    cited 1× open access unreviewed
  6. 6
    Attenuation of Triple Selection Markers to Enhance mAb Expression in Tyrosine-Based Selection Systems via an Inducible CRISPRi Platform.

    Cao L, Zhao L, Zhou Y, Ye Q, Tan WS. · 2026-06-01

    unreviewed
  7. 7
    Dynamics of enzyme and metabolic profile of broilers fed black soldier fly (<i>Hermetiailucens</i>) larvae-based diets.

    Oladejo OA, Ibiwoye DO, Faniyi AA, Ayoola MO, Oguntunji AO, Ayansina AD, Dahunsi SO. · 2026-05-14

    open access unreviewed
  8. 8
    Investigation of the effects and underlying mechanisms of adenylate kinase 1 on inosine monophosphate deposition in Beijing-You chickens.

    Hou J, Zhang Y, Zhu L, Qi X, Wang X, Lin Z, Xiao L, Long C, Dou J, Xu Y, Sheng X. · 2026-03-23

    open access unreviewed
  9. 9
    ATIC Promotes LIHC Progression and Serves as an Independent Prognostic Marker: A Pan-cancer Transcriptomic Analysis.

    Li H, Zhang W, Zhou X, Wu W, Yao F, Zhong H, Zhan N, Chen J, Zhan Y, Yang X. · 2026-05-11

    unreviewed
  10. 10
    Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational Insights.

    Guzmán-Martín CA, González-Moyotl NJ, Juárez-Vicuña Y, Bojalil R, Martínez-Martínez LA, Arenas-Díaz AL, Martí… · 2026-04-07

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.