What it does, reaction by reaction
1 reactions
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
step 11
Irreversible
FAICAR → IMP
› Notes
IMP cyclohydrolase catalyzes FAICAR → IMP + H2O (net ring closure with dehydration/rearrangement as represented by the enzyme mechanism). This completes the six-membered ring and is effectively irreversible under cellular conditions. IMP contains hypoxanthine and is the branch point for AMP and GMP.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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