unreviewed

Hormone-sensitive lipase (HSL; LIPE)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. Activated by PKA (glucagon/epinephrine), inhibited by insulin

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 9 Irreversible/directional

DAG + H2O → monoacylglycerol (MAG) + free fatty acid

Converts Diacylglycerol H2O into Monoacylglycerol (MAG) Fatty acid

› Notes

Hormone-sensitive lipase (HSL; LIPE) hydrolyzes DAG most efficiently; it also has TAG and cholesteryl-ester hydrolase activity. PKA phosphorylation of HSL and perilipin promotes access to the lipid droplet.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Ketogenesis

Listed there as: Hormone-sensitive lipase/ATGL in adipose (upstream fuel supply)

Accelerated by

Catecholamines, glucagon in humans, natriuretic peptides

Inhibited by

Insulin; phosphodiesterase-mediated cAMP degradation

Hormonal control

Low insulin and counterregulatory hormones increase nonesterified-fatty-acid delivery to liver

Triacylglycerol Synthesis and Lipolysis

Listed there as: Hormone-sensitive lipase (HSL)

Accelerated by

PKA phosphorylation; phosphorylation of perilipin; catecholamines/natriuretic peptides

Inhibited by

Dephosphorylation; insulin; phosphodiesterase 3B lowering cAMP

Hormonal control

Epinephrine and norepinephrine activate; insulin strongly inhibits; glucagon has a modest/direct role in human adipocytes compared with catecholamines

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Distinct functional roles of <i>Lactobacillus</i> strains in modulating lipid metabolism, adipose accumulation, inflammatory responses, and carcass characteristics in heavy finishing pigs.
Wan B, Zeng Q, He L, Qin X, Tan M, Yan E, Liao J, Li Z, Zhang X, Yin J. · 2026-07-31

open access unreviewed
2
<i>Bacteroides cellulosilyticus</i>-derived 2-hydroxyphenylacetic acid rectifies hepatic lipid homeostasis in MASLD by targeting the PPARγ-CD36 axis.
Chen K, Yang Z, Peng J, Liu C, Yu Y, Cai X, Liu B, Li S, Chen T, Jung S, Tian Y, Xu Q, Rao X, Wu Z, Wang H, D… · 2026-09-01

open access unreviewed
3
Targeting ROAM1 with UDP-GlcNAc nanosheets selective activates lysosomal AMPK to resolve metabolic dysfunction-associated steatotic liver disease.
Zhu J, Sun T, Wei F, Wang D, Liu F, Chen D, Liu X, Wang C, Deng S, Yang Y, Xiong Y, Xiang H, Li J, Li S, Ma W… · 2026-07-12

open access unreviewed
4
Peptide-functionalized nanoemulsions with exendin-4 as a model ligand.
Holler N, Gesslbauer B, Tam-Amersdorfer C, Letofsky-Papst I, Mayrhofer C, Andreae F, Zimmer A. · 2026-07-02

open access unreviewed
5
Mechanistic insights into the gastroprotective and anti-Helicobacter pylori effects of novel Smyrnium olusatrum extracts through NF-κB, IBA1, and COX-2 modulation.
Terbeche M, Deramchia N, Amari NO, Pachura-Hanusek N, Szumny A, Ouadah K, Zawilak-Pawlik A, Muraszko J, Moos … · 2026-06-11

unreviewed
6
Effects of different caffeine doses on fat oxidation and cardiovascular response during exercise at FATmax in overweight/obese female college students.
Gong Z, Yu S, Lyu Z, Huang W, Zhang T. · 2026-05-12

open access unreviewed
7
Targeting IL-7Rα with PNU-159682 antibody-drug conjugates in acute lymphoblastic leukemia: translational implications.
Yang S, Anzai T, Tsumura R, Fuchigami H, Hamada M, Yuda J, Ikuta K, Yasunaga M. · 2026-04-27

open access unreviewed
8
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W. · 2026-02-22

open access unreviewed
9
Palladium-catalysed synthesis of small-molecule epigenetic inhibitors as anticancer therapeutics.
Sharma R, Rana M, Thakur A, Ojha R, Mousavi SM, Dhingra A, Nepali K. · 2026-02-16

open access unreviewed
10
An acute temperature rise to 40°C inhibits free fatty acid uptake into white adipocytes.
Foti F, Schaepper RS, Konrad D, Wueest S. · 2026-02-11

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.