unreviewed

Hormone-sensitive lipase (HSL; LIPE)

1 reactions · 1 pathways

Cofactors used

H2O

Clinical / pharmacological. Activated by PKA (glucagon/epinephrine), inhibited by insulin

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 9 Irreversible/directional

DAG + H2O → monoacylglycerol (MAG) + free fatty acid

Converts Diacylglycerol H2O into Monoacylglycerol (MAG) Fatty acid

› Notes

Hormone-sensitive lipase (HSL; LIPE) hydrolyzes DAG most efficiently; it also has TAG and cholesteryl-ester hydrolase activity. PKA phosphorylation of HSL and perilipin promotes access to the lipid droplet.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Ketogenesis

Listed there as: Hormone-sensitive lipase/ATGL in adipose (upstream fuel supply)

Accelerated by

Catecholamines, glucagon in humans, natriuretic peptides

Inhibited by

Insulin; phosphodiesterase-mediated cAMP degradation

Hormonal control

Low insulin and counterregulatory hormones increase nonesterified-fatty-acid delivery to liver

Triacylglycerol Synthesis and Lipolysis

Listed there as: Hormone-sensitive lipase (HSL)

Accelerated by

PKA phosphorylation; phosphorylation of perilipin; catecholamines/natriuretic peptides

Inhibited by

Dephosphorylation; insulin; phosphodiesterase 3B lowering cAMP

Hormonal control

Epinephrine and norepinephrine activate; insulin strongly inhibits; glucagon has a modest/direct role in human adipocytes compared with catecholamines

Recent literature

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