Hepatic fructokinase (ketohexokinase)
Cofactors used
Clinical / pharmacological. GCK mutations: MODY2; HK1 deficiency: haemolytic anaemia
What it does, reaction by reaction
Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol
Fructose + ATP → fructose-1-phosphate + ADP
Converts Fructose ATP into Fructose-1-phosphate ADP
› Notes
Hepatic fructokinase (ketohexokinase) uses ATP and Mg2+ to phosphorylate fructose at carbon 1. This reaction is effectively irreversible and has high capacity but is not tightly feedback-regulated; rapid flux can transiently consume ATP and phosphate when fructose intake is very high.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Dual metabolic checkpoint blockade <i>via</i> a 3D-Printed metalloplatform remodels the tumor ecosystem for systemic antitumor immunity.
Meng X, Liu Z, Hao Y, Zhu Y, Gu J, Zhong H, He Y, Fu J. · 2026-08-31
open access unreviewed -
2
Overconsumption of fructose aggravates acute GVHD by inducing gut dysbiosis and promoting macrophage-mediated inflammatory response.
Wu K, Yu H, Cao K, Dai B, Yuan Y, Qian X, Zhong H, Qu Y, Jiang H, Chen T. · 2026-03-13
open access unreviewed -
3
Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism.
He Z, Liu M, Xie Q, Lu H, Guo C. · 2025-12-17
cited 1× open access unreviewed -
4
Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.
Li M, Huang C, Yu S. · 2026-07-02
open access unreviewed -
5
Intestinal-specific ketohexokinase deficiency ameliorates high fructose-induced metabolic dysfunction across the intestinal-liver-kidney axis in mice.
Song S, Yi X, Wang M, Yang H, Tan W, Zhu Y, Yu J, Xu C. · 2026-06-23
unreviewed -
6
Unconventional auricular reconstruction using controlled scaffold buckling and chondrogenic cocktail containing muscle-derived cells.
Huang N, Lee SKJ, Lee KHK, Wen C, Chang Y, Zhang M, Dong C, Mao C, Wang DM, Ker DFE. · 2026-06-10
open access unreviewed -
7
Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease
Chen Y, Li F, Zhang J, Wei M, Ni J, Li T, Yao L, Tian J, Shi J. · 2026-10-01
open access unreviewed -
8
Precision Nutrition as the Concept of Dietary and Nutritional Interventions for Patients With Malignancies: A Narrative Literature Review and Perspectives
Yamaguchi K, Yamanoi K, Ogura J, Koike A, Umemiya M, Higashiyama N, Kou K, Inayama Y, Mizuno R, Miyamoto T, T… · 2026-10-01
open access unreviewed -
9
Posttranslational Modifications of p62/SQSTM1 in Health and Disease.
Wang W, Jiang X, Qiu R, Wijaya CS, Chen M, Wang J, Zhu L, Jin H, Feng L. · 2026-09-30
open access unreviewed -
10
DNA methylation signatures distinguish extranodal NK/T-cell lymphoma and EBV-positive nodal T/NK-cell lymphoma and identify prognostic subgroups.
Phyu T, Leong SM, Chen S, Gu W, Fischer A, Sun QY, Yang H, Syn NL, Deng L, Low LCY, Chuang SS, Kato S, Khoury… · 2026-07-15
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.