Hepatic fructokinase (ketohexokinase)
Cofactors used
Clinical / pharmacological. GCK mutations: MODY2; HK1 deficiency: haemolytic anaemia
What it does, reaction by reaction
Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol
Fructose + ATP → fructose-1-phosphate + ADP
Converts Fructose ATP into Fructose-1-phosphate ADP
› Notes
Hepatic fructokinase (ketohexokinase) uses ATP and Mg2+ to phosphorylate fructose at carbon 1. This reaction is effectively irreversible and has high capacity but is not tightly feedback-regulated; rapid flux can transiently consume ATP and phosphate when fructose intake is very high.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Overconsumption of fructose aggravates acute GVHD by inducing gut dysbiosis and promoting macrophage-mediated inflammatory response.
Wu K, Yu H, Cao K, Dai B, Yuan Y, Qian X, Zhong H, Qu Y, Jiang H, Chen T. · 2026-03-13
open access unreviewed -
2
Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism.
He Z, Liu M, Xie Q, Lu H, Guo C. · 2025-12-17
open access unreviewed -
3
Intestinal-specific ketohexokinase deficiency ameliorates high fructose-induced metabolic dysfunction across the intestinal-liver-kidney axis in mice.
Song S, Yi X, Wang M, Yang H, Tan W, Zhu Y, Yu J, Xu C. · 2026-06-23
unreviewed -
4
Unconventional auricular reconstruction using controlled scaffold buckling and chondrogenic cocktail containing muscle-derived cells.
Huang N, Lee SKJ, Lee KHK, Wen C, Chang Y, Zhang M, Dong C, Mao C, Wang DM, Ker DFE. · 2026-06-10
open access unreviewed -
5
Ketohexokinase: A central mediator of fructose-associated pathogenesis and promising therapeutic target.
Zhang H, Zhu Y, Xu C. · 2026-06-30
unreviewed -
6
Neural focalization of dorsolateral prefrontal cortex and the inferior parietal lobule is associated with inhibitory control performance in adolescence.
Meredith WJ, Guassi Moreira JF, Leal AM, Saragosa-Harris N, Ninova E, Waizman Y, Gaines E, Karlsgodt KH, Silv… · 2026-05-29
open access unreviewed -
7
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Limus-Coated/Eluting Devices in Peripheral Arterial Disease.
Mok MKY, Wu IHC, Yau KHK, Chan YC. · 2025-02-14
unreviewed -
8
Unique nonclinical safety profile of PF-06835919, a ketohexokinase inhibitor, highlights a species-dependent mechanism.
Zhou J, Houle C, Geoly FJ, Campion SN, Cook J. · 2026-07-28
unreviewed -
9
Using Co-Designed Norm-Based Nudges to Promote Mental Health Help-Seeking Intentions Among Older Adults: Protocol for a Randomized Controlled Trial.
Liu T, Liu KHK, Leung DKY, Zhang W, Kwok WW, Wong GHY, Lum TYS. · 2026-07-21
unreviewed -
10
Linking functional and structural dendritic spine remodeling during fear learning and extinction in vivo.
Li X, Zheng Q, Wong KHK, Wong KKY, Lai CSW. · 2026-07-17
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.