What it does, reaction by reaction
Purine Degradation (to Uric Acid) Nucleotide Metabolism · Cytosol
Guanine → xanthine
Converts Guanine into Xanthine
› Notes
Guanine deaminase (guanase) catalyzes guanine + H2O → xanthine + NH3. Xanthine then enters step 7 and is oxidized to uric acid.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Integrated transcriptomics and metabolomics reveal suppression of the PPAR α/γ pathway linking purine metabolism disorder to high-protein diet-induced hyperuricemia in goslings.
Li X, Xie Y, Zhang M, Zou T, Zhong C, Rajput ZI, Bi S, Cao L. · 2026-08-04
open access unreviewed -
2
Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis.
Viola H, Carter H, Griffin K, Costa RM, McDonald R, Callow B, Gonzalez de Los Santos F, Panovich P, Carey S, … · 2026-06-19
open access unreviewed -
3
Phenotypic profiling of neutrophils in acute <i>Clostridioides difficile</i> infection identifies a TNF-induced activation signature associated with epithelial damage.
Huber A, Mathew A, Khondokar F, Sharma D, Mukherjee A, Khona DK, Gabriel J, Jose S, Madan R. · 2026-04-23
open access unreviewed -
4
Hsa_circ_0000711 can serve as a novel biomarker for primary biliary cholangitis by promoting disease progression through the regulation of miR-185-5p and NFATc3.
Lu W, Li W, Wang P, Cong P, Wang Z, Gao W, Sun G, Liu M. · 2026-03-25
open access unreviewed -
5
<i>Fusobacterium nucleatum</i> plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation.
Hou S, Ning T, Liu S, Yang X, Ye H, Zhou Y, Wang C, Zhu J, Lu S, Zhang N, Zhu S. · 2026-01-28
cited 2× open access unreviewed -
6
Spinal Muscular Atrophy in Adult Neurology Services in India.
Mustafa F, Macken WL, Wilson LA, Rani N, Agarwal A, Garg A, Gupta N, Bhatia R, Rajan R, Gupta A, Singh MB, Sa… · 2026-07-31
unreviewed -
7
Clinical Outcomes of Endovascular Treatment for Gastroduodenal and Pancreaticoduodenal Artery Aneurysms.
Kim S, Han Y, Gwon JG, Cho YP. · 2026-07-16
unreviewed -
8
Massive subcapsular hepatic haematoma after laparoscopic cholecystectomy managed by transarterial embolization.
Dinh HH, Woodford R, Gaborit L, Sabat N, Köstenbauer J. · 2026-10-04
open access unreviewed -
9
Interdependence of dental parameters, mandibular mobility and static postural sway as well as load distribution in male subjects of advanced working age.
W C, D K, C E, C MG, G O, D A G, D O. · 2026-10-03
open access unreviewed -
10
Coordinated TNF-NF-κB and PI3K-Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study.
Zhang H, Ren K, Wang S. · 2026-10-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.