Glycolytic enzymes + lactate dehydrogenase (LDHA)
Cofactors used
Clinical / pharmacological. Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
What it does, reaction by reaction
Cori Cycle (lactate shuttle) Carbohydrate Metabolism · Cytosol (muscle) + liver
Glucose -> 2 lactate + 2 ATP (muscle/erythrocyte)
Converts Glucose into Lactate ATP
› Notes
Anaerobic ATP supply; regenerates cytosolic NAD+ so glycolysis can continue.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
<i>Helicobacter pylori</i> activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis.
Chen H, Wang Y, Wang Z, Su W, Shao Y, Zhang G, Wang Z, Ge Y, Zhou X. · 2026-04-22
cited 4× open access unreviewed -
2
Integrated network pharmacology and lipidomics provide insights into potential mechanisms underlying the effects of cannabidiol in a rat model of autism.
Wang H, Zhang Y, Jiang Y, Ren J, Hu J, Wang F, Yang L, Sun C, Wu L, Zou M. · 2026-08-19
unreviewed -
3
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Wang H, Yang S, Xu W. · 2026-10-08
open access unreviewed -
4
GSH-responsive self-assembled nanoplatform synergistically enhances cuproptosis through metabolic reprogramming and oxidative stress amplification.
Huang B, Zhang W, Wang Y, Luo X, Wu W, Shen R, Liu X, Zhang Z, Gao Y, Wu Y, Zeng F, Huang Y, Yu J, Wang S, Wu… · 2026-07-27
open access unreviewed -
5
Extracellular vesicles derived from fetal stem cells in early pregnancy modulate glycolysis and lipid metabolism to induce apoptosis in cancer cells.
Lee J, Cho K, Kim S, Cho E, Kook H, Kang S, Kim J, Cho MH, Nah S, Kwon SH, Kim JC, Jeong H. · 2026-07-27
open access unreviewed -
6
Unbiased plasma proteomics reveals hemolysis during ADAMTS13 relapse in patients with immune TTP.
Postmus T, Subhan MO, Smit ER, Voorberg J, Thomas M, van den Biggelaar M, Scully M, de Groot R, Langerhorst P. · 2026-10-01
open access unreviewed -
7
The Lactate-Lactylation Axis as a Metabolic-Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma.
Yu J, Cui Y, Li S, Guo X, Li N, Gu Y, Jin Y, Chen Y, Li X, Yan Y, Wu Z, Zhu C, Feng L. · 2026-09-16
open access unreviewed -
8
Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response.
Liu Y, Zhou Y, Xue H, Xu R, Liu Y. · 2026-09-10
open access unreviewed -
9
Targeting the KIFC1-SRSF3-PKM Axis Suppresses Cervical Cancer Glycolysis and Enhances Radiosensitivity.
Liu J, Li J, Zhou H, Ha W, Wu X, Liu X, Jiang Y, Gong C, Cheng Y, Liu Q, Chao T, Xiong H. · 2026-09-01
open access unreviewed -
10
Characterization of the metabolome and proteome of stem cell-derived human primordial germ cell-like cells: a multi-omics approach.
Vaz Santos M, Schomakers BV, Ayala ML, Jamali T, van Weeghel M, van Pelt AMM, Mulder CL, Hamer G. · 2026-09-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.