Glycogen synthase
Clinical / pharmacological. GSD 0: low glycogen, fasting ketotic hypoglycaemia
What it does, reaction by reaction
Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)
UDP-glucose + glycogen(n) → glycogen(n+1) + UDP
Converts UDP-glucose Glycogen into Glycogen(n+1) UDP
› Notes
Glycogen synthase transfers glucose from UDP-glucose to a nonreducing end, forming an alpha(1→4) glycosidic bond. This is the principal rate-limiting and committed elongation step; it requires a pre-existing primer and is activated allosterically by glucose-6-phosphate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Glycogenesis (Glycogen Synthesis)
Glucose-6-phosphate; dephosphorylation
Phosphorylation by protein kinase A, glycogen synthase kinase 3, and other kinases
Insulin activates protein phosphatase 1 and inhibits glycogen synthase kinase 3, promoting dephosphorylation/activation; glucagon in liver and epinephrine inhibit through cAMP/protein kinase A
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Ultrasound-responsive nanotherapy promotes axonal regeneration after SCI via reactivating CREB/miR-129-5p signaling.
Gu G, Zhu H, Li S, Zhang Z, Kao Y, Zhang R, Fu R, Han X, Yang Y, Liu H, Liu Q, Gao B, Feng S, Kong X. · 2026-09-22
open access unreviewed -
2
Nanoadjuvant-based membrane poration boosts antitumor immunity via modulating mitochondrial metabolism to downregulate PD-L1 and upregulate STING.
You W, Gao F, Wang HL, Shen AZ, Zhang Z, Nie X, Huang WQ, Wang LH, You YZ. · 2026-09-11
open access unreviewed -
3
ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions.
Pimentel JM, Zhou JY, Wu GS. · 2026-06-24
open access unreviewed -
4
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
5
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress.
Li T, Su T, Tang S, Cao K, Hua P, Gao J, Cui H, Jiang T. · 2026-01-30
open access unreviewed -
6
Methylophiopogonanone A mitigates myocardial ischemia-reperfusion injury: involvement of VEGFR2-associated PI3K/Akt/GSK-3β signaling and suppression of mPTP opening.
Yang M, Deng H, Zhu Q, Qiu W, Zhang Y, Hua J. · 2026-07-22
unreviewed -
7
Short-chain fatty acid-producing commensals: Key modulators of AD neuroinflammation via the microbiota-gut-brain axis.
Ling Z, Huang S, Cheng Y, Liu X, Xu X, Chen Y, Hu P, Wu L, Cai G. · 2026-09-10
open access unreviewed -
8
Molecular insights into triazole-based compounds for triple-negative breast cancer treatment.
Vilangalil A, E S SP, Bukke SPN, V S, Meha N, Thalluri C, Daniel K, Ahikiriza AA. · 2026-09-28
open access unreviewed -
9
NF-κB across the Alzheimer disease spectrum: Context-dependent protective and pathogenic roles.
Azargoonjahromi A, Abutalebian F, Nasiri H. · 2026-08-11
open access unreviewed -
10
Early exercise intervention alleviates neuroinflammation after ischemic stroke by regulating GSK-3β/HK2-associated inflammatory signaling in microglia.
Li N, Wei Y, Wu H, Yuan K, Li C, Hu J, Wu X, Zhang H, Chen X, Wan C. · 2026-08-02
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.