rate-limiting unreviewed

Glycogen synthase

1 reactions · 1 pathways

Clinical / pharmacological. GSD 0: low glycogen, fasting ketotic hypoglycaemia

What it does, reaction by reaction

1 reactions

Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)

step 5 Irreversible/directional rate-limiting

UDP-glucose + glycogen(n) → glycogen(n+1) + UDP

Converts UDP-glucose Glycogen into Glycogen(n+1) UDP

› Notes

Glycogen synthase transfers glucose from UDP-glucose to a nonreducing end, forming an alpha(1→4) glycosidic bond. This is the principal rate-limiting and committed elongation step; it requires a pre-existing primer and is activated allosterically by glucose-6-phosphate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Glycogenesis (Glycogen Synthesis)

Accelerated by

Glucose-6-phosphate; dephosphorylation

Inhibited by

Phosphorylation by protein kinase A, glycogen synthase kinase 3, and other kinases

Hormonal control

Insulin activates protein phosphatase 1 and inhibits glycogen synthase kinase 3, promoting dephosphorylation/activation; glucagon in liver and epinephrine inhibit through cAMP/protein kinase A

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