Glycogen phosphorylase
Cofactors used
Clinical / pharmacological. McArdle disease (GSD V, muscle); Hers disease (GSD VI, liver)
What it does, reaction by reaction
Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism · Cytosol + ER (liver)
Glycogen(n) + Pi → glycogen(n−1) + glucose-1-phosphate
Converts Glycogen(n) Pi into Glycogen(n-1) Glucose-1-phosphate
› Notes
Glycogen phosphorylase uses inorganic phosphate (Pi) and the cofactor pyridoxal phosphate (PLP; vitamin B6) to phosphorolyze successive alpha(1→4) bonds at nonreducing ends. It stops four residues before an alpha(1→6) branch (a limit dextrin); this is the principal rate-limiting step and conserves the bond energy in glucose-1-phosphate rather than using ATP.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Glycogenolysis (Glycogen Breakdown)
Phosphorylation by phosphorylase kinase; AMP in muscle; Ca2+ indirectly through calmodulin on phosphorylase kinase
ATP and glucose-6-phosphate in muscle; glucose in liver promotes inactivation
Glucagon activates liver phosphorylase through cAMP/protein kinase A; epinephrine activates liver and muscle pathways; insulin promotes dephosphorylation/inactivation
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
The impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress.
Hewawansa UHAJ, Henningsen K, Vilela Silva Daniel N, In S, Sugay G, Houghton MJ, Barber E, Williamson G, Cost… · 2026-06-18
open access unreviewed -
2
Carbohydrate supplementation for endurance exercise in the heat: a systematic review with practical recommendations.
Salame A, Brown D, Oueijan K, McCullough D. · 2026-05-09
open access unreviewed -
3
The putative role of the microbiota in the development of neuropsychiatric disorders following early childhood malnutrition.
Jama Y, Khan W, Collins SM. · 2026-03-17
open access unreviewed -
4
Advances in calcium signalling research for the diagnosis and treatment of depression.
Li L, Yao M, Meng J, Zhong Z, Nan N, Kazemi AH, Guo J, Liu C, Jiang Y. · 2026-03-05
cited 1× open access unreviewed -
5
Vitamin D attenuates metabolic dysfunction-associated steatotic liver disease (MASLD) and downregulates hepatic gluconeogenesis in obesity.
Cordeiro MM, Lucredi NC, Pateis VO, Souza GH, Duarte ALR, Scomparin DX, Natali MRM, Sá-Nakanishi AB, Bracht L… · 2026-06-20
unreviewed -
6
Sulforaphane preserves hepatocellular metabolic regulation and organelle integrity in a model of diet-induced obesity.
Ajackson M, Monteiro EB, Martins FF, do Nascimento Junior JX, Cavadas Neto ES, Medeiros Amarante MDS, da Silv… · 2026-06-24
unreviewed -
7
Genotype-phenotype spectrum and clinical outcomes of glycogen storage disease type I: A 15-year experience at Vietnam National Children's Hospital.
Nguyen HT, Vu DC, Cao TV, Tran VK, Bui TP, Can NBT, Nguyen LH, Nguyen NL, Tran TH, Tu NH, Phuong LT, Nguyen K… · 2026-07-10
unreviewed -
8
Association of physiological parameters with final pH in beef.
Maia Júnior RDS, Fernandes EC, Malavazi PFNDS, Souza JRDS, Mesquita AA, de Marchi PGF, Messias CT, Rosa BL. · 2026-06-03
open access unreviewed -
9
Deciphering the impact of light-dark cycles on the interaction between cyanophage YongM and Nostoc sp. FACHB-596.
Sun T, Li Z, Zhu X, Wu Z, Tong Y. · 2026-06-02
unreviewed -
10
NLRP3 deficiency reprograms hepatic glucose metabolism but fails to ameliorate hepatic inflammation and fibrosis in the MCD model.
Zou Y, Wu X, Wang J, Xia J, Zhang S, Ding S, Liu W, Qi Z. · 2025-11-06
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.