What it does, reaction by reaction
Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix
L-glutamine + H₂O → L-glutamate + NH₄⁺
Converts Glutamine H2O into Glutamate NH4+
› Notes
Glutaminase hydrolyzes the amide nitrogen of glutamine in mitochondria; it requires water but no redox cofactor. This irreversible hydrolytic deamidation is not itself oxidative deamination, but it is a major upstream source of mitochondrial glutamate and ammonia in liver, kidney, intestine, and brain.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Real-time NMR analysis of glutamine metabolism for screening anti-cancer agents in living cells.
Lei Y, Huang T, Chai X, Fan X, He S, Liu C, Liu M, Zhang X. · 2026-06-12
open access unreviewed -
2
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.
Xiao W, Tan D, Zeng W, Nie X, Wang M. · 2026-01-28
open access unreviewed -
3
Gut bacteria and their metabolites may influence our decisions, intelligence, cognition, and consciousness.
Dicks LMT, Botha A, Pohl C. · 2026-10-03
open access unreviewed -
4
Immunometabolism and rheumatic disease-advancing targeted therapies.
Boothby MR. · 2026-09-22
open access unreviewed -
5
Evaluation of Cardiac Function After Stereotactic Body Radiation Therapy for Lung Tumors: Results of the Prospective Explorative Heart-Lung Study.
Hoeksema WF, Belderbos J, Dieleman EMT, van Doorn-Wink K, de Bruin-Bon HACM, van der Ree MH, Visser J, Hopman… · 2026-09-18
open access unreviewed -
6
Effects of dietary supplements on lower-limb power and jump performance in physically active individuals and athletes: a systematic review and Bayesian network meta-analysis.
Sun R, Su M, Xu X, Wang N, Li Z, Sun X, Lin W, Wang H. · 2026-10-01
open access unreviewed -
7
Cycloserine inhibits glutamate decarboxylase from <i>Mycobacterium tuberculosis</i>.
Snášel J, Dostál J, Tupec M, Bulvas O, Pichová I. · 2026-09-21
open access unreviewed -
8
The hemodynamic cost of intermittent hemodialysis and systemic organ stunning.
Jiang Z, Zhong L, Fang J, Liu C, Ji R, Hu Y, Zhao X, Qi W. · 2026-09-21
open access unreviewed -
9
Hepatocyte SLC31A1-dependent copper accumulation contributes to hepatic glucose and lipid metabolic disturbances through AMPKα1 inactivation.
Cheng YQ, Wei M, Yang L, Zhuang YY, Lu QB. · 2026-09-11
open access unreviewed -
10
Targeting the gut-bone axis in osteoporosis: probiotic interventions and other microbiota-based therapeutic strategies.
Zhao K, Zhang Z, Tang Z, Man X, Liu J, Feng R, Li K, Jiang Y, Li T. · 2026-09-17
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.