What it does, reaction by reaction
Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix
L-glutamine + H₂O → L-glutamate + NH₄⁺
Converts Glutamine H2O into Glutamate NH4+
› Notes
Glutaminase hydrolyzes the amide nitrogen of glutamine in mitochondria; it requires water but no redox cofactor. This irreversible hydrolytic deamidation is not itself oxidative deamination, but it is a major upstream source of mitochondrial glutamate and ammonia in liver, kidney, intestine, and brain.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Real-time NMR analysis of glutamine metabolism for screening anti-cancer agents in living cells.
Lei Y, Huang T, Chai X, Fan X, He S, Liu C, Liu M, Zhang X. · 2026-06-12
unreviewed -
2
Multiple machine learning models for predicting major adverse cardiovascular events in dialysis with clinical and echocardiographic parameters: a retrospective cohort study.
Jin M, Lin Z, Ma L, Li B, Huang X, Chen M. · 2026-07-10
unreviewed -
3
MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15
open access unreviewed -
4
The regulatory roles of non-coding RNAs in aerobic glycolysis and therapeutic potential in pancreatic ductal adenocarcinoma.
Fan Y, Tang X, Li S, Liu S, Fang Y, Sun X, Xue Z, Niu H, Chen Y, Dai C, Ling R. · 2026-06-09
open access unreviewed -
5
Pathogenicity and Virulence of <i>Fusarium oxysporum</i> f. sp. <i>vasinfectum</i> Race 4: Understanding an Emerging Threat to Cotton from Field to Genome.
Zhou Y, Zhang H, Martin TK, Chagoya J, Isakeit T, Shim WB. · 2026-06-10
open access unreviewed -
6
Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis.
Liu C, Liu S, Lu Z, Cao X, Tong X, Sun I, Hao J, Zhang L. · 2026-05-26
open access unreviewed -
7
Gut microbiota and immunometabolism in obesity.
Torres-Mayo A, Liébana-García R, Olivares M, Pellón A, Anguita J, Sanz Y. · 2026-05-05
cited 1× open access unreviewed -
8
Effects of race distance and probiotics intervention on kidney, muscle, and gut injury and inflammation biomarker responses during running.
Hansson E, Skinner B, Falcone T, Halder A, Lucas RAI. · 2026-04-14
open access unreviewed -
9
Effectiveness of self-management interventions in reducing cancer treatment-related cardiotoxicity in breast cancer survivors: A systematic review.
Yang M, Yang Q, Tse G, Ma Y, Lyu QY, Wang W, Lai AY, Zhang Y, Wong CWM, Liu X. · 2026-03-02
open access unreviewed -
10
Stochastic neural dynamic modeling and analysis under environmental noise for exploring the production of K-complexes.
Wang W, Song J, Zan W, Wang B, Li Y, Zhang R. · 2026-04-03
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.