What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
Ceramide + UDP-glucose -> glucosylceramide + UDP
Converts Ceramide UDP-glucose into Glucosylceramide UDP
› Notes
Entry to the glycosphingolipid/ganglioside series; sequential glycosyltransferases then build lactosylceramide, globosides and gangliosides.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Homocystinuria symptomatology collected through an international patient-report data program as a source for natural history data.
Parke B, Bartke D, Beek G, Talebizadeh Z, Chapman KA, Baker J, Thomas JA. · 2026-09-11
open access unreviewed -
2
Molecular mechanisms of neuroendocrine regulation of molting in the Chinese mitten crab (Eriocheir sinensis): A transcriptomic analysis based on eyestalk ablation model.
Fu C, Fu X, Li Z, Li F, Wang L, Dong Y. · 2026-07-30
unreviewed -
3
Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis.
Ashok D, Manjrekar PA, Shetty BC, Sailet SS. · 2026-10-01
open access unreviewed -
4
BmK IT2 suppresses proliferation while differentially modulates migration and invasion of neural tumor cells: Association with down-regulation of functional VGSCs and transcriptional reprogramming.
Jing S, Wang J, Cheng S, Ma Q, Tao J, Wang H, Ji Y, Tan Z, Zhou Y. · 2026-05-25
unreviewed -
5
Glucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death
· 2026-09-22
open access unreviewed -
6
Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia.
Luo D, Zhan Y, Ji L, Xu P, Chen P, Pang H, Ling Y, Hua F, Zhuang X, Chen H, Cheng Y. · 2026-09-27
open access unreviewed -
7
T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.
Li Q, Guan J, Song Y, Yang H, Li G, Zhao X, Liu J, Liu B, Tan Y, Zhou H, Zhang YH, Wang Y. · 2026-09-27
open access unreviewed -
8
<i>Fusobacterium</i><i>nucleatum</i>-Stimulated OSCC Cell-Derived Exosomes Induce a Pro-Adhesive Phenotype in Lymphatic Endothelial Cells <i>via</i> the ROS/NF-κB/ICAM1 Axis.
Wei L, He Q, Gao H, Li W, Sun T, Feng Q. · 2026-09-05
open access unreviewed -
9
Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
Moriggi M, Ruggiero L, Torretta E, Zoppi D, Arosio B, Fiorillo C, Nigro V, Capitanio D, Gelfi C. · 2026-09-14
open access unreviewed -
10
Glycan reachability analysis: A bottleneck-aware framework for inferring tissue-specific glycan biosynthetic potential from transcriptomics.
Matsui Y. · 2026-09-24
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.