Galactose-1-phosphate uridylyltransferase (GALT)
Clinical / pharmacological. Classic galactosaemia: cataracts, jaundice, E. coli sepsis, intellectual disability
What it does, reaction by reaction
Galactose Metabolism Carbohydrate Metabolism · Cytosol
Galactose-1-phosphate + UDP-glucose → glucose-1-phosphate + UDP-galactose
Converts Galactose-1-phosphate UDP-glucose into Glucose-1-phosphate UDP-galactose
› Notes
Galactose-1-phosphate uridylyltransferase (GALT) exchanges uridyl groups. This central Leloir reaction requires the activated-sugar substrate UDP-glucose; it is reversible, but physiologic flux is directed toward glucose-1-phosphate formation. It is the critical/committed processing step for galactose-1-phosphate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Galactose Metabolism
Listed there as: Galactose-1-phosphate uridylyltransferase
Galactose-1-phosphate and UDP-glucose availability
Product accumulation; inherited loss causes substrate trapping
No major acute hormonal control
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
2
Recent advances and clinical relevance of microbiome dynamics in health and disease.
Gavanji S, Suhail M, Bencurova E, Dandekar T, Othman EM. · 2026-06-12
open access unreviewed -
3
Nanomaterial-based vaccines: An advanced approach against rotavirus: A review article.
Soroush Fard A, Kalantar K, Teimoori A, Barati M, Arezumand R, Fani M. · 2026-06-11
open access unreviewed -
4
Repurposing the antispasmodic drug pinaverium bromide as a novel antifungal agent and synergist against <i>Candida albicans</i>.
Yao J, Yang Z, Hang X, Chen T, Li B, Shi T, Quan K, Xu J, Zeng L, Feng G, Bi H. · 2026-06-01
open access unreviewed -
5
The impact of gut microbiota and metabolite-driven immune cell spatiotemporal dynamics on tumors.
Ding JB, Lin MX, Zang D, Chen J. · 2026-05-28
open access unreviewed -
6
Immune discrimination between commensals and pathogenic bacteria.
Alanazi HH. · 2026-05-22
open access unreviewed -
7
A comprehensive review of regulatory mechanisms of novel enterotoxin genes in <i>Staphylococcus aureus</i> from meat sources.
Guan Z, Shi Y, Tian X, Jin C, Guan Z, Guan Z. · 2026-05-04
open access unreviewed -
8
Targeting the gut-kidney axis to improve kidney transplantation prognosis: from mechanisms to clinical intervention strategies.
Cao H, Sun J, Lv Y, Ye J, Wang Y, Jiang H. · 2026-03-17
cited 1× open access unreviewed -
9
Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate.
Nirachonkul W, Farrell MP, Tolbert TJ, Okonogi S, Tima S, Anuchapreeda S, Chiampanichayakul S, Siahaan TJ. · 2026-03-05
open access unreviewed -
10
Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.
Benedé-Ubieto R, Estévez-Vázquez O, Acar R, Leal-Lassalle H, Gutierrez AH, Redondo-Urzainqui A, Iborra S, Odi… · 2026-02-21
cited 2× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.