Galactose-1-phosphate uridylyltransferase (GALT)
Clinical / pharmacological. Classic galactosaemia: cataracts, jaundice, E. coli sepsis, intellectual disability
What it does, reaction by reaction
Galactose Metabolism Carbohydrate Metabolism · Cytosol
Galactose-1-phosphate + UDP-glucose → glucose-1-phosphate + UDP-galactose
Converts Galactose-1-phosphate UDP-glucose into Glucose-1-phosphate UDP-galactose
› Notes
Galactose-1-phosphate uridylyltransferase (GALT) exchanges uridyl groups. This central Leloir reaction requires the activated-sugar substrate UDP-glucose; it is reversible, but physiologic flux is directed toward glucose-1-phosphate formation. It is the critical/committed processing step for galactose-1-phosphate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Galactose Metabolism
Listed there as: Galactose-1-phosphate uridylyltransferase
Galactose-1-phosphate and UDP-glucose availability
Product accumulation; inherited loss causes substrate trapping
No major acute hormonal control
Recent literature
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