Skip to content
MS
Sign in
unreviewed

GMP synthetase

1 reactions · 1 pathways

Cofactors used

ATP H2O PPi

What it does, reaction by reaction

1 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 15 Irreversible

XMP → GMP

Converts Xanthosine monophosphate (XMP) into GMP

› Notes

GMP synthetase catalyzes XMP + glutamine + ATP + H2O → GMP + glutamate + AMP + PPi. ATP is cleaved to AMP and PPi, and the enzyme channels glutamine-derived ammonia to an adenylated XMP intermediate; thus this step consumes two high-energy phosphate equivalents and is effectively irreversible.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

  1. 1
    CD69 blockade restores the bone marrow niche and delays leukemogenesis in a mouse model of <i>Nras</i> <sup>G12D</sup>-driven chronic myelomonocytic leukemia.

    Li Y, Jiang X, Gu Y, Zha X, Wu J, Wu X, Qi C, Chen S, Li Y, Jin Z, Xia C, Xu L. · 2026-06-22

    open access unreviewed
  2. 2
    Local delivery of SBRT and IL-12 to murine PDAC tumors modulates hematopoiesis.

    Vrooman TG, Quarato ER, Hannon G, Salama NA, Lesch ML, Hughson AL, Chandak VS, Vdovichenko N, Jin Z, Lakony R… · 2026-06-05

    open access unreviewed
  3. 3
    Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy.

    Gallo R, Scarano A, Gianquinto E, Franzini G, Antonini G, Montalbano S, Palmieri C, Conti P, Spyrakis F, Bors… · 2026-05-11

    open access unreviewed
  4. 4
    Gut microbiota dysbiosis exacerbates acute pancreatitis via <i>Escherichia coli</i>-driven neutrophil heterogeneity and NETosis.

    Zou Y, Li N, Li X, Kuang M, Xu X, Guan L, Li X, Zheng P, Li L, Wan J, Lu N, Liu J, He C, Zhu Y. · 2025-12-24

    cited 2× open access unreviewed
  5. 5
    Bone marrow immunosuppressive states associate with survival after guadecitabine and atezolizumab therapy in HMA-R/R MDS.

    Jang HJ, Urrutia G, Ørskov AD, Nguyen AV, Kim HJ, Nelson SA, Lee H, Burgos RS, Johnson BK, Wegener M, Becker … · 2026-05-05

    open access unreviewed
  6. 6
    Human CD34 as a biomarker and functional tool in progenitor cell isolation: A comprehensive review.

    Woodard GE. · 2026-05-24

    unreviewed
  7. 7
    The use of edible insects in human food.

    de Oliveira PB, Fonseca HC, Vieira CR, de Carvalho GGP, Dos Coimbra JSDR, de Carvalho Mesquita BMA. · 2026-01-23

    open access unreviewed
  8. 8
    Discovery of a small-molecule inhibitor targeting human GMP synthetase.

    Wang Z, Sundarraj R, Mao B, Ma JA, Mei K, Yuchi Z. · 2025-12-19

    unreviewed
  9. 9
    Identification of poplar and spruce GDP-mannose pyrophosphorylases involved in mannan and ascorbic acid biosynthesis.

    Guevara-Rozo S, Mansfield SD. · 2026-07-28

    unreviewed
  10. 10
    Evolocumab protects mice from radiation-induced damage by affecting hematopoietic cell lineage.

    Gan Y, Zhou J, Li B, Huang D, Ma Y, Pei L, Sheng K, Zhang L, Cheng Y, Du J, Cai S, Liu C. · 2026-06-13

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.