What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
XMP → GMP
Converts Xanthosine monophosphate (XMP) into GMP
› Notes
GMP synthetase catalyzes XMP + glutamine + ATP + H2O → GMP + glutamate + AMP + PPi. ATP is cleaved to AMP and PPi, and the enzyme channels glutamine-derived ammonia to an adenylated XMP intermediate; thus this step consumes two high-energy phosphate equivalents and is effectively irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration.
Yin H, Li Y, Zhu Y, Yan Z, Han Y, Cheng F, Hu J, Ma J, Xing X, Yang C, Tian H, Chen W, Zhang Y. · 2026-08-30
open access unreviewed -
2
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency.
Yu L, Zhou B, Liu W, Li W, Wei Q, Zhang Y, Li C, Li W, Li Y, Li G, Sun G, Gan R, Chen R, Zhang W, Zeng A, Zha… · 2026-05-12
open access unreviewed -
3
Forage particle size, rather than dietary iNDF concentration, affects chewing activity and lactation performance in lactating dairy goats.
Soufizadeh M, Pirmohammadi R, Alijoo YA, Khalilvandi-Behroozyar H, Asadnezhad B, Salem AZM. · 2026-07-24
open access unreviewed -
4
Optimization strategies for monoclonal antibody production: advances in simulation and artificial intelligence in bioprocessing.
Kubra K, Shaik MA. · 2026-07-24
open access unreviewed -
5
Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of <i>Yarrowia lipolytica</i>.
Mihalchik AL, Roberts A, LaCombe J, Lloyd M, Doepker C, Eapen A. · 2026-06-20
open access unreviewed -
6
CD69 blockade restores the bone marrow niche and delays leukemogenesis in a mouse model of <i>Nras</i> <sup>G12D</sup>-driven chronic myelomonocytic leukemia.
Li Y, Jiang X, Gu Y, Zha X, Wu J, Wu X, Qi C, Chen S, Li Y, Jin Z, Xia C, Xu L. · 2026-06-22
cited 1× open access unreviewed -
7
Local delivery of SBRT and IL-12 to murine PDAC tumors modulates hematopoiesis.
Vrooman TG, Quarato ER, Hannon G, Salama NA, Lesch ML, Hughson AL, Chandak VS, Vdovichenko N, Jin Z, Lakony R… · 2026-06-05
open access unreviewed -
8
Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy.
Gallo R, Scarano A, Gianquinto E, Franzini G, Antonini G, Montalbano S, Palmieri C, Conti P, Spyrakis F, Bors… · 2026-05-11
open access unreviewed -
9
Gut microbiota dysbiosis exacerbates acute pancreatitis via <i>Escherichia coli</i>-driven neutrophil heterogeneity and NETosis.
Zou Y, Li N, Li X, Kuang M, Xu X, Guan L, Li X, Zheng P, Li L, Wan J, Lu N, Liu J, He C, Zhu Y. · 2025-12-24
cited 4× open access unreviewed -
10
Monocytes in pneumonia: Functional plasticity and innate memory (Review).
Li RZ, Xie ZH, Chen L, Shang YX, Wang F, Huang WJ, Cheng Q. · 2026-09-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.