What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
XMP → GMP
Converts Xanthosine monophosphate (XMP) into GMP
› Notes
GMP synthetase catalyzes XMP + glutamine + ATP + H2O → GMP + glutamate + AMP + PPi. ATP is cleaved to AMP and PPi, and the enzyme channels glutamine-derived ammonia to an adenylated XMP intermediate; thus this step consumes two high-energy phosphate equivalents and is effectively irreversible.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.
Europe PMC · ten most recent, newest first