GAR transformylase (GART)
Cofactors used
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
10-Formyl-THF + glycinamide ribonucleotide (GAR) → formyl-GAR + THF
Converts 10-Formyl-THF Glycinamide ribonucleotide (GAR) into Formylglycinamide ribonucleotide (FGAR) Tetrahydrofolate (THF)
› Notes
GAR transformylase (the phosphoribosylglycinamide formyltransferase domain of GART) donates one formyl group during de novo purine synthesis. This reaction is a committed folate-dependent input into the purine pathway after early purine assembly has begun.
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
GAR → formylglycinamide ribonucleotide (FGAR)
Converts Glycinamide ribonucleotide (GAR) into Formylglycinamide ribonucleotide (FGAR)
› Notes
GAR transformylase transfers a formyl group: GAR + 10-formyl-THF → FGAR + THF. This is the first of two folate-dependent one-carbon transfer steps and introduces C8 of the purine ring.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
A nationwide prospective randomized trial for diagnosing developmental disorders demonstrates genome sequencing outperforms standard of care.
Geysens M, Souche E, Baroni MC, Benoit V, Beyltjens T, Bossuyt W, Bours V, Crabbé M, Croes D, De Smet M, Dési… · 2026-10-05
open access unreviewed -
2
Confidence Intervals for a Proportion Estimated From Pooled Samples Based on Firth's Corrected Score.
Biggerstaff BJ, Hepworth G. · 2026-10-01
open access unreviewed -
3
A spatial and temporal transcriptomic atlas of mouse intestinal regeneration in the jejunum.
Ofer R, Tran T, He P, Qiu X, Hu X, Zachariah E, Krier C, Saxena A, Chen L, Yang J, Verzi MP. · 2026-09-03
open access unreviewed -
4
Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis.
Hall B, Ebrahim YM, Sharpe JL, Makhija S, Ellis BCS, Wong KE, Walker H, Yagüe-Capilla M, Timmons HO, Bradley … · 2026-09-16
open access unreviewed -
5
Genotype-guided antiretroviral therapy outcomes in routine clinical practice: a retrospective study of HIV viral load suppression at 6 and 12 months in Uganda.
Ankunda C, Emunyu J, Namasambi S, Sserunjogi C, Kyomuhangi B, Mumbere I, Nakawesi J. · 2026-09-15
unreviewed -
6
Single-Cell Transcriptomics of Pyrimidine Salvage in HBV-Related HCC Reveals Prognostic and Immune Infiltration Features.
Xie L, Wang S, Lin T. · 2026-08-31
open access unreviewed -
7
Nanoplastics exacerbate DSS-induced colitis via histone lactate axis.
Tian S, Hu Y, Zou J, Hao N, Liu J, Li R, Li J. · 2026-08-20
unreviewed -
8
Dissecting residual disease in spheroids reveals pan-cancer persistence signatures and a therapeutic window for oncolytic viruses.
Fauveau C, Lawendy E, Deforges J, Cochin S, Moreau B, Balloul JM, Erbs P, Jain S, Laverny G, PERSIST-SEQ Cons… · 2026-06-19
open access unreviewed -
9
Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).
Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03
open access unreviewed -
10
Asymmetric Functional Divergence of <i>alx4a</i> and <i>alx4b</i> in Iridophore Differentiation and Cranial Development in Nile Tilapia.
Shi H, Fang F, Yao J, Ju S, Li M, Wang D. · 2026-08-22
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.