Fumarylacetoacetate hydrolase (FAH)
Cofactors used
Clinical / pharmacological. Tyrosinaemia type I: liver failure, renal Fanconi, cabbage odour; treated with nitisinone
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Fumarylacetoacetate + H₂O → fumarate + acetoacetate
Converts Fumarylacetoacetate H2O into Fumarate Acetoacetate
› Notes
Fumarylacetoacetate hydrolase (FAH) yields one glucogenic product (fumarate) and one ketogenic product (acetoacetate). This establishes phenylalanine and tyrosine as both glucogenic and ketogenic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment.
Saxton SH, Kang I, Mitchell S, Lotto J, Upadhyay A, Zou C, Quirk C, McCray TN, Prado O, Johansson F, Fortin C… · 2026-07-23
open access unreviewed - 2
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3
Heavy metal contamination in cosmetic hair dyes, dermal health risk assessment, and in vivo toxicological implications among exposed women in Khartoum, Sudan.
Mohamed FAH, Al-Hadiya BMH, Alghadi RY, Abadi RSM, Bakheit AH. · 2026-08-26
open access unreviewed -
4
Effects of cassava wax immersion on pain, pressure pain threshold, and upper extremity function among patients with trigger finger.
Khamnon N, Buttagat V, Punyanitya S, Kaewjoho C, Kluayhomthong S, Areeudomwong P. · 2026-05-26
open access unreviewed -
5
Cross-Sectional coaxial technique: optimizing specimen adequacy and safety in ultrasound-guided renal biopsy procedures.
Huang L, Zhan X, Chen L, Zhang J, Luo N, Wang Y, Wang D, Liu J, Ren L, Li M, Yang Q, Luo H. · 2026-08-18
open access unreviewed -
6
Ginger-based formulations for allergic rhinitis disease: a systematic review and meta-analysis of experimental studies in animals and humans.
Inpan R, Kantasa T, Hanprasertpong N, Na Takuathung M, Koonrungsesomboon N. · 2026-05-25
open access unreviewed -
7
Growth, Carcass Quality and Gut Microbiota Responses to Extruded Rapeseed Meal With Protease in Broiler Chickens.
Hameed R, Tahir M, Khan RU, Ahmad S, Rossi L, Al-Akeel RK. · 2026-11-01
open access unreviewed -
8
Development and validation of a multiparametric MRI habitat radiomics nomogram for predicting early complete response to induction chemoimmunotherapy in locally advanced nasopharyngeal carcinoma.
Zhu B, Chen K, Wen Z, Zhu L, Li L, Zhu X. · 2026-07-28
unreviewed -
9
Author Correction: Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics.
Wannigama DL, Amarasiri M, Phattharapornjaroen P, Hurst C, Modchang C, Besa JJV, Miyanaga K, Cui L, Fernandez… · 2026-10-01
open access unreviewed -
10
A noncanonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer.
Högström J, Doh HM, Kump A, Petrova B, Wang P, Lee JD, Koivula K, Kozlova N, Cruz KA, Hong SM, Perea C, Garg … · 2026-09-30
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.