Fumarylacetoacetate hydrolase (FAH)
Cofactors used
Clinical / pharmacological. Tyrosinaemia type I: liver failure, renal Fanconi, cabbage odour; treated with nitisinone
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Fumarylacetoacetate + H₂O → fumarate + acetoacetate
Converts Fumarylacetoacetate H2O into Fumarate Acetoacetate
› Notes
Fumarylacetoacetate hydrolase (FAH) yields one glucogenic product (fumarate) and one ketogenic product (acetoacetate). This establishes phenylalanine and tyrosine as both glucogenic and ketogenic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Ginger-based formulations for allergic rhinitis disease: a systematic review and meta-analysis of experimental studies in animals and humans.
Inpan R, Kantasa T, Hanprasertpong N, Na Takuathung M, Koonrungsesomboon N. · 2026-05-25
open access unreviewed -
2
Neuroprotective effect of Urukku Velichenna (Traditionally processed virgin coconut oil) in Parkinson's disease: Bridging ethnopharmacology and experimental validation using in vitro, in vivo, and in silico models.
Deepika NP, Sharma R, Banerjee S, Verma T, Prajapati PK, Muhasina KM, Parihar VS, Kondengadan SM, Duraiswamy … · 2026-05-29
unreviewed -
3
Molecular prevalence and socioeconomic, demographic, and behavioral risk factors of <i>Chlamydia trachomatis, Neisseria gonorrhoeae</i>, and <i>Ureaplasma</i> species among women in Mogadishu, Somalia.
Mohamoud JH, Adam MH, Mohamed AMS, Garba B, Mohamud AK, Dahie HA, Asowe HA, Orey FAH, Nur MAS, Adawe M, Hassa… · 2026-06-06
unreviewed -
4
Hypoxia-induced downregulation of cAMP drives Ganoderic acid biosynthesis and restricts biofilm development in Ganoderma lucidum.
Wang S, Tian L, Li F, Wang Q, Tan Y, Ning Y, Cao X, Liu Y, Shangguan J, Li H, Jiang A, Zhao M, Hyde KD, Ren A. · 2026-05-28
unreviewed -
5
Enhancing the antioxidant and phenolic profiles of fermented mulberry leaf (Morus alba L.) tea using symbiotic culture of bacteria and yeast.
Tay MY, Wilai M, Chu CC, Mai T, Chew SC. · 2026-05-20
unreviewed -
6
Effects of Mindfulness-Based Interventions (MBI) on Blood Pressure Among Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Reangsing C, Punsuwun S, Oerther S. · 2026-04-17
unreviewed -
7
Advancing Emergency Nursing Care Through International Collaboration and Behaviour Change Theory.
Considine J, Chuajedton P, Suthipong C, Dhuvakham W, Wiangosot S, van Gulik N, Pintatham K, Shaban RZ, Curtis… · 2026-02-15
unreviewed -
8
The Efficacy of Low-Temperature Atmospheric-Pressure Plasma (LTAPP) in the Multicenter Treatment of Pressure Ulcers: A Randomized Controlled Trial.
Tonaree W, Taweepraditpol S, Kongkunnavat N, Poungjantaradej N, Kotistienkul B, Yongsuvimol M, Chinaroonchai … · 2025-03-16
cited 1× unreviewed -
9
Acute and Chronic Toxicity Tests and Assessment of In Vitro and In Vivo Anti-Allergic Effects of Prabchompoothaweep Remedy.
Makchuchit S, Pusiripinyo P, Jai-Uea A, Kuropakornpong P, Sireeratawong S, Khonsung P, Davies NM, Itharat A. · 2026-08-05
unreviewed -
10
Structure-based classification of bacterial chitooligosaccharide-specific outer membrane porins (ChiPs).
Amornloetwattana R, Bunkum P, Soysa HSM, Baslé A, Aunkham A, Robinson RC, van den Berg B, Suginta W. · 2026-08-12
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.