Fumarase (fumarate hydratase)
Cofactors used
Clinical / pharmacological. FH mutations: hereditary leiomyomatosis and renal cell carcinoma
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Fumarate + H2O ⇌ L-malate
Converts Fumarate H2O into Malate
› Notes
Required cofactor: none beyond water. The reaction is reversible and forms only L-malate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
A Review on the Geometry of the Conharmonic Curvature Tensor of Almost Hermitian and Almost Contact Metric Manifolds.
Abood HM, AlHusseini FH. · 2026-07-28
unreviewed -
2
Validation of mitochondrial <i>COX3</i> primers for quantitative PCR-based authentication of chicken-derived products.
Azka SB, Barido FH, Volkandari SD, Utama DT, Erwanto Y, Cahyadi M. · 2026-06-26
unreviewed -
3
Effects of intraoperative low-dose remimazolam maintenance on emergence agitation and emergence time in patients undergoing oral surgery: protocol for a randomized controlled trial.
Hu X, Fu C, Bi G, Tan Q, Ying Y, Zhao W, Cai X, Yin N, Wang X, Liu H, Meng L, Ji FH, Sun Q, Zhao B, Liu H. · 2026-07-11
unreviewed -
4
Efficacy and safety of cabozantinib plus nivolumab in advanced non-clear cell renal cell carcinoma: a nationwide multicenter study.
Kim CG, Kim J, Kim IH, Jung EH, Im HS, Kang BW, Park JH, Park JH, Jo J, Kim EJ, Beom SH, Rha SY, Kim SH, Park… · 2026-06-28
unreviewed -
5
Molecular characterisation of extended-Spectrum-Beta-lactamase-producing <i>Klebsiella pneumoniae</i> among children and chicken in the rural Korogwe District, Tanzania.
Mbwana JR, Thye T, Krumkamp R, Frickmann H, Lusingu JPA, Minja DTR, Khan NA, Akenten CW, Chercos DH, Kaseka J… · 2026-06-12
open access unreviewed -
6
The current landscape and future directions of Lyme disease vaccines.
Chen Z, He L, Huang X, Liang X, Liu A, Bao F. · 2026-06-22
open access unreviewed -
7
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
8
Expanding optimization ensemble model methods for forecasting seasonal influenza in the U.S.
Longaou BB, Löster R, Yue P, Lyver D, van Bommel CM, Thommes EW, Cojocaru MG. · 2026-06-01
open access unreviewed -
9
Extracellular vesicles subpopulation derived of clonal mesenchymal stem cells protected retinal ganglion cells in mouse model with optic nerve crush.
Satarian L, Eslami N, Saeedi-Fard R, Yektadoost E, Shojaei A, Hosseini Mazinani FS, Taghiyar L, Poosti S, Naz… · 2026-06-06
open access unreviewed -
10
Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathway.
Zhou D, Xiong T, Yang B, Liu F, Mo X, Chen T, Lu P, Liang X, Li L, Qin Y, Lu D, Huang F, Yang X. · 2026-06-04
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.