unreviewed

Ferrochelatase (FECH)

1 reactions · 1 pathways

Cofactors used

Fe2+ · Iron Heme/cytochrome · Iron

Clinical / pharmacological. Erythropoietic protoporphyria; also inhibited by lead

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 8 Irreversible

Protoporphyrin IX + Fe²⁺ → heme (protoheme IX) + 2 H⁺

Converts Protoporphyrin IX Fe2+ into Heme (protoheme IX) H+

› Notes

Ferrochelatase (FECH) inserts ferrous iron into protoporphyrin IX on the matrix side of the inner mitochondrial membrane. This final step requires bioavailable Fe²⁺ and is effectively irreversible; lead also inhibits ferrochelatase.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Biosynthesis (Porphyrin Pathway)

Listed there as: Ferrochelatase

Accelerated by

Ferrous iron availability; intact mitochondrial iron delivery

Inhibited by

Lead; iron deficiency; FECH pathogenic variants

Hormonal control

Indirectly coupled to erythropoiesis and iron-regulatory signaling

Recent literature

Refresh

Europe PMC · from cache · sorted by publication date

1
Development and characterization of a topical ferrochelatase inhibitor nanoemulsion for choroidal neovascularization therapy.
Mohapatra D, Seo SY, Corson TW. · 2026-07-17

unreviewed
2
From 18 F-choline to prostate-specific membrane antigen PET: lessons from early multiparametric kinetic modelling in prostate cancer.
Haroon A, Almuhaideb A, Adeleke S, Endozo R, Erlandsson K, Syed GMS, Emberton M, Bomanji J. · 2026-05-19

unreviewed
3
FECH, a novel metabolic target influencing CAR T-cell phenotype and function.
Pellegrino M, Vespa S, Salvatori I, Mac GD, Valle C, Secli V, Cairoli S, Goffredo BM, Caforio M, Folgiero V, … · 2026-08-12

unreviewed
4
Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs.
Peroni E, Pizzi M, Basso M, Atanasio A, Calistri E, Gottardi M, Rosato A. · 2026-08-03

unreviewed
5
Liver transcriptomics reveals dysregulated hepatic absorption, distribution, metabolism, and excretion signatures in a mouse model of erythropoietic protoporphyria.
Sun ZY, Gu R, Qin FY, Bao Y, Lu J, Zhang M, Yang D, Zhong XB, Zhu J, Ma X. · 2026-07-15

unreviewed
6
Cascade Amplification of Photoimmunotherapy via Mitochondrial Dual-Ion Interference in a Bimetallic-Organic Framework.
Cao Z, Jiao J, Wang Q, Su H, Feng S, Zhang R, Xin R, Ma Q, Zheng N, Li K, Liu S, He L, Liu S. · 2026-07-31

unreviewed
7
AI-driven structure- and ligand-based discovery of novel Ferrochelatase inhibitors from heterocyclic libraries.
Cho SC, Wang YW, Chu CA, Huang MC, Pangging M, Lee CT. · 2026-07-25

unreviewed
8
Transcriptome Sequencing Reveals That Curcumin Protects Leghorn Chicken Cardiomyocytes from Heat Stress-Induced Iron Dysregulation.
Bian M, Zeng X, Zhang D, Bu J, Bai D. · 2026-07-15

unreviewed
9
High Operating Potential Induces Conversion in Li-Rich Chalcogenides.
Mishra A, Davis VK, Dulock NV, Patheria ES, Dalleska NF, See KA. · 2026-07-05

unreviewed
10
The structural chemistry and biosynthesis of chlorophylls.
Hunter CN, Morey-Burrows FS. · 2026-06-25

open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.