unreviewed
FAD-dependent dehydrogenase step (BCAA branch)
1 reactions · 1 pathways
What it does, reaction by reaction
1 reactions
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
step 8
Irreversible/directional
Valine-derived isobutyryl-CoA → methacrylyl-CoA → 3-hydroxyisobutyryl-CoA → methylmalonate semialdehyde → propionyl-CoA → succinyl-CoA
Converts Valine-derived isobutyryl-CoA into Methacrylyl-CoA
› Notes
FAD-dependent dehydrogenation, hydration, hydrolysis, NAD⁺-dependent oxidation, and the biotin- and adenosylcobalamin-dependent propionyl-CoA pathway yield succinyl-CoA. Therefore valine is glucogenic.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
No articles returned.