What it does, reaction by reaction
Phase I - Functionalization Xenobiotic & Drug Metabolism · Smooth ER (microsomes), mitochondria
Ester or amide + H2O -> acid + alcohol/amine
Converts Ester or amide H2O into Alcohol/amine
› Notes
Non-CYP hydrolysis, e.g. aspirin to salicylate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Betulin-Amino Acid Molecular Hybrids: Synthesis, Structure and Pharmacological Potential.
Grymel M, Naprawca P, Dolniak-Budny D, Tomczyk MD, Pielok M, Nowrot B, Skutnik K, Erfurt K, Lalik A. · 2026-05-15
open access unreviewed -
2
Biological treatment strategies for antibiotic contamination: mechanisms, applications, and future perspectives.
Zhao X, Xie E, Xie H. · 2026-05-15
open access unreviewed -
3
Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with <i>In Vivo</i> Efficacy against Drug-Resistant <i>Neisseria gonorrhoeae</i>.
Tharra PR, Youse MS, Abutaleb NS, Abdelsattar AS, Holly KJ, Nocentini A, Abouelkhair AA, Metcalfe CK, Liao CJ… · 2026-05-06
open access unreviewed -
4
Comparative toxicity and biochemical impacts of certain recommended insecticides against Spodoptera littoralis (Lepidoptera: Noctuidae).
El-Morshedy AE, Shalaby AAM, Al-Shannaf HMH, Mahmoud MG, Ibrahim HAM, Hendawi MY. · 2026-04-28
open access unreviewed -
5
Toxicometabolomics Characterization of Two N1-Sulfonated Dimethyltryptamine Derivatives in Zebrafish Larvae and Human Liver S9 Fractions Using Liquid Chromatography-High-Resolution Mass Spectrometry.
Punnamraju P, Manier SK, Hemmer S, Grill M, Schippers P, Herrmann J, Meyer MR. · 2026-02-14
open access unreviewed -
6
Mechanism and evolutionary divergence of a novel oxidized polyvinyl alcohol hydrolase in Stenotrophomonas rhizophila QL-P4.
Zhou Y, Bold N, Feng J, Jia C, Huang K, Yao Y, Qiu L, Chen S, Huang L, Wei Y. · 2026-01-27
open access unreviewed -
7
Insights into the toxicity effects of indoxacarb against Spodoptera frugiperda using metabolomics combined with mass spectrometry imaging.
Ma L, Shao X, Tang Y, Yang S, Li Z, Zhang Z, Xu H, Wu X. · 2025-09-08
unreviewed -
8
Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates.
Shriwas P, Noonchester AM, Revnew A, Lane TR, Hadad CM, Ekins S, McElroy CA. · 2025-12-19
open access unreviewed -
9
Harnessing the bioremediation potential of indigenous Pseudomonas stutzeri for textile effluent treatment: a mechanistic insight.
Bhayana T, Gupta S, Dubey AK. · 2025-11-17
open access unreviewed -
10
Bottom Sediments as Dynamic Arenas for Anthropogenic Pollutants: Profiling Sources, Unraveling Fate Mechanisms, and Assessing Ecological Consequences.
Maqsood A, Łobos-Moysa E. · 2025-10-21
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.