What it does, reaction by reaction
Phase I - Functionalization Xenobiotic & Drug Metabolism · Smooth ER (microsomes), mitochondria
Ester or amide + H2O -> acid + alcohol/amine
Converts Ester or amide H2O into Alcohol/amine
› Notes
Non-CYP hydrolysis, e.g. aspirin to salicylate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Acinetobacter guillouiae, a lipolytic strain isolated from sludge capable of partially depolymerising polyethylene terephthalate: genomic, proteomic, and biochemical insights.
Akhtar N, Najjari A, Magnone A, Yerebakan EC, Bernfur K, Tullberg C, Awan MS, Majeed Z, Grey C, Zhang B, Lina… · 2026-08-26
open access unreviewed -
2
Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes.
Krug O, Guddat S, Görgens C, Walpurgis K, Toma F, Thomas A, Thevis M. · 2026-05-28
open access unreviewed -
3
Biotransformation of Coumarins: Mechanisms and Pharmaceutical Potential.
Saragih M, Szczepańska E, Olejniczak T. · 2026-07-24
open access unreviewed -
4
Spontaneous Non-Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications.
Cai Y, Zhao C. · 2026-05-25
open access unreviewed -
5
Betulin-Amino Acid Molecular Hybrids: Synthesis, Structure and Pharmacological Potential.
Grymel M, Naprawca P, Dolniak-Budny D, Tomczyk MD, Pielok M, Nowrot B, Skutnik K, Erfurt K, Lalik A. · 2026-05-15
open access unreviewed -
6
Biological treatment strategies for antibiotic contamination: mechanisms, applications, and future perspectives.
Zhao X, Xie E, Xie H. · 2026-05-15
cited 1× open access unreviewed -
7
Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with <i>In Vivo</i> Efficacy against Drug-Resistant <i>Neisseria gonorrhoeae</i>.
Tharra PR, Youse MS, Abutaleb NS, Abdelsattar AS, Holly KJ, Nocentini A, Abouelkhair AA, Metcalfe CK, Liao CJ… · 2026-05-06
open access unreviewed -
8
Comparative toxicity and biochemical impacts of certain recommended insecticides against Spodoptera littoralis (Lepidoptera: Noctuidae).
El-Morshedy AE, Shalaby AAM, Al-Shannaf HMH, Mahmoud MG, Ibrahim HAM, Hendawi MY. · 2026-04-28
open access unreviewed -
9
Unique structural and ligand-binding properties of the <i>Staphylococcus aureus</i> serine hydrolase FphE.
Jo J, Upadhyay T, You X, Bennett JM, Lee H, Bogyo M, Fellner M. · 2026-03-24
cited 1× open access unreviewed -
10
Toxicometabolomics Characterization of Two N1-Sulfonated Dimethyltryptamine Derivatives in Zebrafish Larvae and Human Liver S9 Fractions Using Liquid Chromatography-High-Resolution Mass Spectrometry.
Punnamraju P, Manier SK, Hemmer S, Grill M, Schippers P, Herrmann J, Meyer MR. · 2026-02-14
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.