What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
trans-Δ2-Enoyl-CoA + H2O → L-3-hydroxyacyl-CoA
Converts trans-Delta-2-Enoyl-CoA H2O into L-3-Hydroxyacyl-CoA
› Notes
Enoyl-CoA hydratase (crotonase) hydrates the double bond stereospecifically. No redox cofactor is required.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Toxico-multi-omics approach to evaluate pentachlorophenol toxicity in zebrafish: Integration of metabolome and proteome.
Han H, Lee HK, Ko R, Kim JH, Song MH, Lee JH. · 2026-07-10
unreviewed -
2
SUMOylation activates ECHS1 for adaptive catabolism in lung cancer.
Chen Y, Mao H, Cai L, Li Q, Song J, Zhang M, Chen S, Ai Z, Xiong Q, Liu K, Lin X, Tan H, Wang T, Fan Q, Zuo Y… · 2026-07-09
unreviewed -
3
Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming.
Duan CH, Liu PP, Sun X, Ma WH, Pang JY, Zhang ZH, Li X, Jiao LF, Du HZ, Teng ZQ, Chen HZ, Liu CM. · 2026-07-01
unreviewed -
4
Disruption of ER-mitochondria contact sites by coronavirus replication organelles sustains viral replication via NSP3 stabilization.
Zheng X, Hu L, Long X, Zhao Z, Chen R, Bai R, Tian B, Zhou M, Ding B, Xu T, Li Z. · 2026-05-28
unreviewed -
5
Lactylation landscape of mitochondrial proteins in myocardial infarction.
Kadam A, Kashyap S, Samantaray K, Jaiswal N, Goyani S, Kramer PA, Hadi P, Lee J, Furdui CM, Jadiya P, Tomar D. · 2026-05-18
open access unreviewed -
6
Hypertension Drives Protein Lactylation and Vascular Dysfunction in Skeletal Muscle.
Fontes MT, Townsend P, Butler L, Parente JM, Araujo FA, Costa TJ, Bomfim GF, Pernomian L, Tan W, VanderVeen B… · 2026-04-22
unreviewed -
7
AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors.
Min J, Schweizer L, Zonderland G, Selvanesan BC, Thomsen JH, Oldenburg L, Bae SW, Kim B, Hernández SD, Jez G,… · 2026-07-01
open access unreviewed -
8
Artificial mitochondria ameliorates osteoarthritis through restoring cellular energy metabolism homeostasis.
Yan W, Chen Y, Wu H, Gao Z, Hu X, Ao Y, Mao C, Wan M. · 2026-03-04
open access unreviewed -
9
Neohesperidin Regulates Lipid Metabolism and Ameliorates MASLD by Targeting ECHS1.
Zhu H, Zhu T, Yang M, Huang X, Gao S, Li M, Shu Y, Yu X, Ke X, Zhang J, Qi J. · 2026-06-29
unreviewed -
10
Lipid Metabolic Reprogramming and Epigenetic Co-Dysregulation Across the Central Chondrosarcoma Grade Spectrum: A Multi-Cohort RNA-seq Study
Ayhan B, Dönmez N, Ayhan Z. · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.