What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
trans-Δ2-Enoyl-CoA + H2O → L-3-hydroxyacyl-CoA
Converts trans-Delta-2-Enoyl-CoA H2O into L-3-Hydroxyacyl-CoA
› Notes
Enoyl-CoA hydratase (crotonase) hydrates the double bond stereospecifically. No redox cofactor is required.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study.
Wang J, Yuan T, Wei Q, Xie K, Zhang J. · 2026-07-08
open access unreviewed -
2
Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency.
Keshavan N, Neugebauer J, Bellusci M, Bertini E, Brown G, Darin N, DeBrosse S, Drexler L, Drexler S, Enns GM,… · 2026-11-01
cited 1× open access unreviewed -
3
Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth.
Marie C, Baskaran IN, Corre R, Mayeur A, Grynberg M, Chevreux G, L'Hôte D, Cohen-Tannoudji J, Chauvin S. · 2026-10-01
open access unreviewed -
4
Short-chain enoyl-CoA hydratase deficiency: a systematic review of clinical spectrum, genotype-phenotype correlations and survival predictors.
Banerjee S, Ghoshal A, Chowdhoury SR. · 2026-10-02
unreviewed -
5
Protective <i>IFIH1</i> variant reduces islet stress and dysfunction in a type 1 diabetes genetic background.
Veronese-Paniagua DA, Banks C, Bradley K, Mukherjee N, Gale SE, Hinshaw KE, Meacham AM, Iwaloye OF, Tse HM, M… · 2026-09-17
open access unreviewed -
6
Mitochondria-to-plasma-membrane H<sub>2</sub>O<sub>2</sub> signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells.
Klöppel E, Engstová H, Duspiva P, Tauber J, Mozheitova O, Jabůrek M, Ježek P. · 2026-07-16
open access unreviewed -
7
Sex-related transcriptomic differences in idiopathic pulmonary fibrosis.
Menon AA, Moll M, Pugashetti JV, Linderholm AL, Liu GY, Krishna R, Ma SF, Noth I, Hunninghake GM, Feghali-Bos… · 2026-10-01
unreviewed -
8
Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.
Varderidou-Minasian S, Jakobs CE, Pasteuning-Vuhman S, Gal L, Timmers A, Altelaar M, Lorenowicz MJ, Pasterkam… · 2026-02-05
open access unreviewed -
9
Integrated Multi-Omic Analyses Reveal Gender-Specific Molecular Mechanisms Regulating Growth and Muscle Development in Zhongshan Partridge Ducks.
Ouyang T, Chao X, Yin Y, Ji C, Ma X, He Y, Cui T, Zhong H, Wu Z, Luo Q. · 2026-09-14
open access unreviewed -
10
FABP4/5-Mediated Lipid Reprogramming Is Associated with Immunosuppressive T Cell Crosstalk in Cervical Cancer After Chemoradiotherapy.
Xu T, Ma M, Zhang J, Wang Y, Tang X, Wu S. · 2026-09-15
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.