What it does, reaction by reaction
Pyrimidine Degradation Nucleotide Metabolism · Cytosol
5,6-Dihydrouracil → N-carbamyl-beta-alanine
Converts 5,6-Dihydrouracil into N-Carbamyl-beta-alanine
› Notes
Dihydropyrimidinase hydrolyzes the reduced ring: 5,6-dihydrouracil + H2O → N-carbamyl-beta-alanine. This metalloenzyme opens the pyrimidine ring.
5,6-Dihydrothymine → N-carbamyl-beta-aminoisobutyrate
Converts 5,6-Dihydrothymine into N-Carbamyl-beta-aminoisobutyrate
› Notes
Dihydropyrimidinase catalyzes 5,6-dihydrothymine + H2O → N-carbamyl-beta-aminoisobutyrate.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Pyrimidine Degradation
Dihydropyrimidine availability
Product accumulation; inherited loss of function
No established direct hormonal control.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Low-dose l-carnitine supplementation attenuates hepatic lipid accumulation in chow-fed mice: Insights from integrated multi-omics analysis.
Zhang Z, Ding B, Zhang L, Zhang L, Huang Y. · 2026-09-10
open access unreviewed -
2
Occupationally relevant vibrations and the brain: frequency-dependent proteomics signatures in a rat model.
Chao D, Milosavljevic S, Thompson B, Julseth L, Chumala P, Tomilin M, Lang A, Howland JG, Katselis GS. · 2026-08-09
open access unreviewed -
3
Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy.
Chen J, Wang Y, Xu L, Li X, Zhao L. · 2026-02-27
cited 1× open access unreviewed -
4
Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the <i>AOC1</i> gene: a randomized double-blind placebo-controlled study.
Ferrer-Garcia J, Navarro MD, Abadias M, López-García R, Sansalvador A, Gris G, Uscamaita K. · 2025-12-01
open access unreviewed -
5
Identification of a Ste20-like kinase-dependent signaling network orchestrating cytoskeletal and synaptic development of cortical neurons.
Quatraccioni A, Graham ME, Sylvester M, Hardt R, van Waardenberg AJ, Becker AJ, Schoch S. · 2026-10-02
open access unreviewed -
6
The Fbxw11-Dpysl2 ubiquitin axis restrains the progression of acute myeloid leukemia.
Wang L, Li Y, Xie W, Li R, Cui X, Zhang S, Ren Q, Zheng G. · 2026-08-12
unreviewed -
7
Gene variants associated with pediatric-onset erythromelalgia: Mendelian and rare-variant association analyses.
Yonas MC, Ocay DD, Genetti CA, Lobo K, Fernandes M, Groussis N, Halpin M, Wilder RT, Yu TW, Berde CB, Brownst… · 2026-08-03
open access unreviewed -
8
The Silent Vehicle: Validating the Biological Signals and Noises of Baculovirus Vectors in Macrophage-Targeted Vaccines.
Ridwan B, Salmanida FP, Wahyuningtyas R, Lai YS, Wu ML, Chung WB, Chang CT, Chang KT. · 2026-09-16
open access unreviewed -
9
An Unbiased Drug Screen in a Drosophila Model of <i>LMNA</i>-Muscular Dystrophy Identifies Calcium Channel Blockers as Potential Treatments.
Mohar NP, Powers BA, Hinz BE, Bock AR, McCoy-Munger H, Darr Z, Shumaker MW, Wemmie AT, Saxena A, Wallrath LL. · 2026-09-19
open access unreviewed -
10
Allelic Variants of the <i>DPYD</i> Gene in Russian Patients with Cancer: The Results of Exome Sequencing.
Fedorinov D, Lyadov V, Lyadova M, Abdullaev S, Sychev I, Filatova A, Danilov L, Glotov O, Budagova I, Mirzaev… · 2026-09-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.