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unreviewed

Dihydropyrimidinase

2 reactions · 1 pathways

Cofactors used

H2O

What it does, reaction by reaction

2 reactions

Pyrimidine Degradation Nucleotide Metabolism · Cytosol

step 8 Irreversible/directional

5,6-Dihydrouracil → N-carbamyl-beta-alanine

Converts 5,6-Dihydrouracil into N-Carbamyl-beta-alanine

› Notes

Dihydropyrimidinase hydrolyzes the reduced ring: 5,6-dihydrouracil + H2O → N-carbamyl-beta-alanine. This metalloenzyme opens the pyrimidine ring.

step 9 Irreversible/directional

5,6-Dihydrothymine → N-carbamyl-beta-aminoisobutyrate

Converts 5,6-Dihydrothymine into N-Carbamyl-beta-aminoisobutyrate

› Notes

Dihydropyrimidinase catalyzes 5,6-dihydrothymine + H2O → N-carbamyl-beta-aminoisobutyrate.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pyrimidine Degradation

Accelerated by

Dihydropyrimidine availability

Inhibited by

Product accumulation; inherited loss of function

Hormonal control

No established direct hormonal control.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy.

    Chen J, Wang Y, Xu L, Li X, Zhao L. · 2026-02-27

    open access unreviewed
  2. 2
    Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the <i>AOC1</i> gene: a randomized double-blind placebo-controlled study.

    Ferrer-Garcia J, Navarro MD, Abadias M, López-García R, Sansalvador A, Gris G, Uscamaita K. · 2025-12-01

    open access unreviewed
  3. 3
    Gene variants associated with pediatric-onset erythromelalgia: Mendelian and rare-variant association analyses.

    Yonas MC, Ocay DD, Genetti CA, Lobo K, Fernandes M, Groussis N, Halpin M, Wilder RT, Yu TW, Berde CB, Brownst… · 2026-08-03

    unreviewed
  4. 4
    Transcriptomic profiling of oocyte maturation in allotetraploid hybrid fish and identification of HSD17b12 mediating DHP synthesis.

    Liao S, Diao D, Miao Y, Liang H, Song G, Liu J, Zhang M, E Z, Lu D, Lin H, Li S, Zhang Y. · 2026-05-22

    unreviewed
  5. 5
    The Fbxw11-Dpysl2 ubiquitin axis restrains the progression of acute myeloid leukemia.

    Wang L, Li Y, Xie W, Li R, Cui X, Zhang S, Ren Q, Zheng G. · 2026-08-12

    unreviewed
  6. 6
    Visible-Light-Promoted Carbamoylation: Access to Diarylhydrazine Carbonyl Amino Acid/Peptide Derivatives.

    Zeng FL, Wang L, Luo YX, Yuan J, Yu B, Loh TP. · 2026-06-30

    unreviewed
  7. 7
    Blocking β-alanine synthesis triggers widespread perturbations of energy and lipid metabolism in the brain.

    Homaei SC, Mahootchi E, Srivastava A, Gomladu MS, Krokengen OC, Baumann A, Haavik J. · 2026-05-23

    open access unreviewed
  8. 8
    Optimizing anti-seizure medication selection for epilepsy in EAST/SeSAME syndrome: Insights from DrugBank and STRING databases.

    Hu LY, Wan L, Han F, Huang Y, Zhu G, Cao WQ, He W, Shi XY, Yang G, Zou LP. · 2025-09-09

    open access unreviewed
  9. 9
    Proteomic profiling identifies an oncogene ITGA2 and its downstream targets in gastric cancer.

    Liu MX, Chu KM. · 2026-02-02

    open access unreviewed
  10. 10
    BMX-001 acts as a selective chemoradioprotector in rectal cancer.

    Myers MS, Kosmacek EA, Liew CS, Chatterjee A, Wojtkiewicz M, Roy P, Hyde RK, Dhawan P, Spasojevic I, Wang S, … · 2026-03-12

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.