What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
3-Ketosphinganine + NADPH -> sphinganine + NADP+
Converts 3-Ketosphinganine NADPH into Sphinganine NADP+
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Proteome Responses to Acute Inhibition of De Novo Sphingolipid Synthesis Suggest Cancer Combination Therapies.
Luu TTT, Zhang D, Bheemanapally K, Zaman M, Wu Z, Liu Y, Wu X, Kim HE, Zheng L, Ogretmen B, Peng J, Du G. · 2026-06-02
open access unreviewed -
2
Novel <i>LIPC</i>-related recessive form of postural proprioceptive deficits in Brown Swiss cattle.
Weber BA, Zimmermann A, Häfliger IM, Seefried FR, Meylan M, Drögemüller C, Jacinto J. · 2026-04-02
open access unreviewed -
3
Identification of Novel Risk Loci for Common B-Cell Lymphoma Subtypes Through Cross-Trait Analysis with Idiopathic Inflammatory Myopathies.
Che WI, Jarvis JN, International Lymphoma Epidemiology Consortium InterLymph, Imacs Genetics Group Myogen, Lu… · 2026-05-09
open access unreviewed -
4
Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model.
Morigny P, Ji H, Cussonneau L, Zorzato S, Kwon Y, Riols F, Kaltenecker D, Maier A, Karthikaisamy V, Corrà S, … · 2026-05-15
cited 1× open access unreviewed -
5
Vitamin D remodels the tumor microenvironment to suppress gastric cancer progression through cancer-associated fibroblasts-secreted exosomal miR-378c targeting KDSR.
Li Q, Liu Y, Zhong L, Ye W, Wu X, Shen J, Xiao Z, Zhao Y, Du F, Xu Z, Chen Y, Lan X, Ye B, Yuan D, Lu L, Cho … · 2026-05-09
unreviewed -
6
Complicated Spastic Paraparesis: Study of a Patient With a De Novo Pathogenic Variant in ELOVL1.
Vaia Y, Mura E, Bruschi F, Zambrano S, Brena M, Tadini G, Arrigoni F, Antonello CE, Uggetti C, Parazzini C, V… · 2026-05-01
open access unreviewed -
7
Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.
Tang S, Yao X, Wang S, Zhu F, Zeng W, Lai D, Meng X, Zhang X, Zhu Z, Zhang T, Xu R. · 2026-05-07
open access unreviewed -
8
Behind the membranous curtain-lipid dynamics and functions in coronaviral replication.
Salisch F, Müller-Ruttloff C. · 2026-04-21
open access unreviewed -
9
Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer.
Babuta J, Gruevska A, Wickremesinghe C, Montoya A, Roumelioti G, Shliaha P, Balcells C, McKinney F, Bray C, A… · 2026-04-16
open access unreviewed -
10
Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling.
Liu H, Aili A, Kuang Z, Cao L, Li Z, Shang Y, Ge Y, Hu T, Sun Y, Zhao W, Jin R, Chang C, Chang C. · 2026-03-13
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.