What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
3-Ketosphinganine + NADPH -> sphinganine + NADP+
Converts 3-Ketosphinganine NADPH into Sphinganine NADP+
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis.
Hoertel N, Mühle C, Müller CP, Chaieb H, Scheer V, Fayad M, Sánchez-Rico M, Limosin F, Kornhuber J. · 2026-05-13
cited 1× open access unreviewed -
2
Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
Moriggi M, Ruggiero L, Torretta E, Zoppi D, Arosio B, Fiorillo C, Nigro V, Capitanio D, Gelfi C. · 2026-09-14
open access unreviewed -
3
Cucumber Mosaic Virus Promotes Sphingolipid Biosynthesis to Alleviate Host Unfolded Protein Response (UPR)-Mediated Immunity.
Yao J, Wu S, Gao S, Xiang Z, Wang Q, Ye F, Liao Q, Gu Z, Du Z. · 2026-09-01
open access unreviewed -
4
Genome analysis of the glycosphingolipid-producing green alga tetraselmis sp. NKG400013.
Yasui R, Hosaka A, Ogata N, Ogawa T, Yohda M, Arakaki A, Kataoka K, Tanaka T. · 2026-09-01
open access unreviewed -
5
Function of <i>HIF-1α</i> in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in <i>Callosobruchus chinensis</i> Under Hypoxia.
Li X, Cui S, Wan Z, Sun X, Liu Y, Geng X, Lu Y. · 2026-08-28
open access unreviewed -
6
Sphingolipid Metabolism Links Morphological Signatures to Immunomodulatory Potency in Human Mesenchymal Stromal Cells.
Shah DC, Leitmann BW, Priyadarshani P, DeVeaux SA, Munoz C, Zhang Y, Rui K, Chiappa NF, Hymel LA, York W, Ogl… · 2026-08-27
open access unreviewed -
7
Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture.
Tittelmeier J, Sandhof CA, Martin N, El-Kabarity D, Ngonza-Nito SB, Melki R, Nussbaum-Krammer C. · 2026-08-27
cited 3× open access unreviewed -
8
Sphingolipid Metabolism in Oral Diseases: Pathogenic Mechanisms, Biomarkers, and Therapeutic Opportunities.
Zang S, Huang J, Duan N, Wang W, Wang X, Peng Q, Han W. · 2026-08-12
open access unreviewed -
9
Transcription Factor Regulation of Epidermal Differentiation and Inflammation.
Batzorig U, Zhang G, Sen GL. · 2026-08-18
open access unreviewed -
10
Special Issue: EACR 2026 Congress: Innovative Cancer Science, 8-11 June 2026.
· 2026-08-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.