What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
Carbamoyl aspartate → dihydroorotate
Converts Carbamoyl aspartate into Dihydroorotate
› Notes
Dihydroorotase catalyzes intramolecular cyclization/dehydration: carbamoyl aspartate ⇌ L-dihydroorotate + H2O. This zinc-dependent enzyme is the third CAD activity.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Benefit of Linked-Color Imaging in Artificial Intelligence-Assisted Diagnosis of Early Gastric Cancer: A Pilot Study With Propensity Score Adjustment.
Mohamed AN, Minoda Y, Maruoka R, Suzuki Y, Fukuya H, Tsuru H, Wada M, Tanaka Y, Chinen T, Moriyama T, Ogino H… · 2026-07-28
unreviewed -
2
Agreement and workflow efficiency of AI-based coronary artery calcification quantification in lung cancer screening: Comparison with semi-automated and visual assessment.
Ochs K, Ensle F, Happe J, Jungblut L, Frauenfelder T, Kroschke J. · 2026-07-18
unreviewed -
3
Coronary artery calcium scoring using virtual vs. true non-contrast images from ultra-high-resolution and normal-resolution photon-counting coronary CT angiography.
Engel S, Shahzadi I, Haag NP, Gertz RJ, Niehoff JH, Surov A, Borggrefe J, Kroeger JR. · 2026-07-04
unreviewed -
4
Analyzing the impact of ionizable lipid identity, purity, and stability on lipid nanoparticle performance.
Rubio-Prego I, Beck-Broichsitter M, Samaridou E, Alonso MJ, Simon J. · 2026-06-27
unreviewed -
5
Co-occurring diabetes and depression and their impact on CVD, CAD, and stroke risk over a 10-year follow-up: A cohort study.
Ghazaee H, Mahdavizadeh V, Rezaee A, Darroudi S, Rezaee M, Esmaily H, Mehrabzadeh M, Shahabi HE, Sajadiyeh HS… · 2026-06-19
unreviewed -
6
Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.
Wang L, Lu Y, Pan H, Li X, Luo L. · 2026-06-19
open access unreviewed -
7
Elevated atherogenic index of plasma is associated with severe acute kidney injury in critically ill patients with cardiovascular disease - a MIMIC-IV analysis with external validation in the eICU-CRD database.
Liu P, Shen Q, Liu Y, Hong K. · 2026-06-18
open access unreviewed -
8
High-throughput signal detection of hepatotoxic drug-drug interactions in hospitalized elderly patients: an NLP-driven pharmacovigilance study.
Ma J, Chen H, Guo C, He G, Yang G. · 2026-06-17
open access unreviewed -
9
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
10
Proteomic Mendelian randomization and machine learning reveal causal plasma biomarkers in cardiorenal comorbidity.
Huang H, Liu W, Yan Y, Cao J, Wang J, Fang C. · 2026-06-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.