Enzyme or protein defect
ALA dehydratase and ferrochelatase
Accumulates or becomes deficient
ALA, protoporphyrin (zinc protoporphyrin)
Key features
Microcytic anaemia with basophilic stippling, abdominal colic, wrist/foot drop, encephalopathy, gingival lead lines
Management
Chelation (succimer, EDTA, dimercaprol)
Not clinical guidance. Written from standard clinical biochemistry, not from the uploaded documents, and marked unreviewed. Teaching-level reference for study and database seeding only. It must not be used to manage a patient.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Exogenous pipecolic acid ameliorates lead-induced phytotoxicity in chili (<i>Capsicum annuum</i> L.) by enhancing antioxidant capacity and physiological homeostasis.
Iqbal R, Mehmood H, Majeed A, Murtaza G, Huseynova A, Ullah S, Ditta A, Aldahmash B, Rady A. · 2026-06-01
cited 1× open access unreviewed -
2
Microalgae as novel drug-delivery system for biomedical field.
Dai Y, Guo D, Li A, Chen W, Yang Y, Li S, Yang L, Feng S. · 2026-01-27
cited 1× open access unreviewed -
3
Advances in the clinical applications of sodium thiosulphate.
Deng Y, Ke J, Zang H, Liu Y, Wang P. · 2026-01-05
cited 5× open access unreviewed -
4
Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine
Song L, Silli E, Xu Y, Lv H, Song R. · 2026-10-01
open access unreviewed -
5
Childhood Lead‐Exposure Prevention Through Predictive Mapping of At‐Risk Housing Nationwide: A Free, Public‐Data Screening Map Checked Against Measured Blood Lead in 11 States
Ritter E. · 2026-10-01
open access unreviewed -
6
Iron and Other Metal Ions in Human Health and Disease.
Dai X, Li J. · 2026-10-02
open access unreviewed -
7
Examining Trends in Early Childhood Lead Exposure Using the National Poison Data System: 2007-2024.
Ebersole JM, Hallett TC, Kieszak S, Schnall AH, Yeh M. · 2026-09-28
unreviewed -
8
The role of metals in cancer and the use of metal chelators as a potential treatment strategy.
Leal MFC, Rocha DA, Cardoso IL. · 2026-07-20
open access unreviewed -
9
Lead in Drinking Water and Child Health: Evidence From Jackson, Mississippi.
Chang E, Kennedy K, Mallatt J. · 2026-07-01
cited 1× unreviewed -
10
Ascorbic Acid as a Dual Therapeutic and Preventive Agent against Lead and Cadmium Toxicity: Evidence from Controlled Quail Experiments.
Mousa S, Zyoud AH, Shawahna R. · 2026-06-29
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.