Dihydrofolate (DHF)
Reactions involving Dihydrofolate (DHF)
Every recorded step where this molecule takes part
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Dihydrofolate (DHF) + NADPH + H⁺ → tetrahydrofolate (THF) + NADP⁺
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DHF → THF
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DHF → THF; THF → 5,10-methylene-THF
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5,10-Methylene-THF + dUMP → dTMP + DHF
Showing all 4 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| One-Carbon Metabolism (Folate Cycle) | → | Deoxyribonucleotide Formation (Ribonucleoti… | cross-category |
| One-Carbon Metabolism (Folate Cycle) | → | Pyrimidine De Novo Synthesis (through to UM… | cross-category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.
Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M. · 2026-06-24
open access unreviewed -
2
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
open access unreviewed -
3
Replication stress induced exposure to methotrexate in root meristem cells of Vicia faba.
Aneta Ż, Gocek-Szczurtek N, Wróblewski M, Cieślak K, Polit JT. · 2026-06-19
open access unreviewed -
4
Causal link between folic acid and recurrent aphthous ulcers: A two-sample Mendelian randomization study.
Gao T, Chen T, Xu Y, He L, Hou Y, Gong M. · 2026-06-01
open access unreviewed -
5
A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications.
Khanduja R, Frye RE. · 2026-06-03
open access unreviewed -
6
Engineering Protein Stability with Small Molecules: A Review of the ecDHFR Destabilizing Domain System.
Ruhinda M, Olmo RP, Burini BC. · 2026-06-09
open access unreviewed -
7
One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.
Al Qassab M, Bou Ghanem A, Hussayni Y, Kadbey R, Ratel Y, Yehya S, Zahr M, Ghadieh HE, Abi Khattar Z, Azar S,… · 2026-03-17
open access unreviewed -
8
The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision.
Wang Y, LaBapuchi, Liu M, Chen L. · 2025-09-19
cited 1× open access unreviewed -
9
Reassessing Mandatory Folic Acid Fortification for Neural Tube Defect Prevention: Evidence, Uncertainty, and Policy Implications.
Westmark CJ. · 2026-05-30
open access unreviewed -
10
Optimisation of Micronutrient Supplementation During Pregnancy: Interactions Between Bioactive Compounds, Their Impact on Health, and Regulatory Considerations.
Makó RA, Sipos P. · 2026-04-05
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.