Dihydrofolate (DHF)
Reactions involving Dihydrofolate (DHF)
Every recorded step where this molecule takes part
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Dihydrofolate (DHF) + NADPH + H⁺ → tetrahydrofolate (THF) + NADP⁺
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DHF → THF
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DHF → THF; THF → 5,10-methylene-THF
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5,10-Methylene-THF + dUMP → dTMP + DHF
Showing all 4 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| One-Carbon Metabolism (Folate Cycle) | → | Deoxyribonucleotide Formation (Ribonucleoti… | cross-category |
| One-Carbon Metabolism (Folate Cycle) | → | Pyrimidine De Novo Synthesis (through to UM… | cross-category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Comprehensive safety assessment of novel dicholine folate vitamin.
Jonaitis T, Ulmann M, Wiesler G, Lukasik KV. · 2026-07-15
open access unreviewed -
2
Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives.
Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M. · 2026-06-24
open access unreviewed -
3
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
cited 2× open access unreviewed -
4
Folate transporters at the plasma membrane of fungi and plants: specificity, mechanism of transport, and importance
Vashist N, Bachhawat A. · 2026-10-01
open access unreviewed -
5
Mitochondrial NADP(H)-dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors.
Li Q, Shu T, Liu C, Zheng M, Li Y, Zhang L, Fan G, Lu W, Zhang H, Liu P, He X, Zheng H, Liu W, Ye J, Yin Z, D… · 2026-09-24
open access unreviewed -
6
Temporal Hydrogen-Bond Network Analysis Reveals Substrate-Directed Connectivity in Dihydrofolate Reductase.
Guclu TF, Atilgan C, Atilgan AR. · 2026-09-21
unreviewed -
7
Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review.
Frye RE, Rossignol DA. · 2026-09-03
open access unreviewed -
8
Antiplasmodial Compounds from <i>Eurycoma harmandiana</i> Pierre and <i>Eurycoma longifolia</i> Jack Against Drug-Resistant <i>Plasmodium falciparum</i>: An Integrated In Vitro and In Silico Study.
Konyanee A, Wahab HA, Kamarulzaman EE, Suhaimi AMM, Ismail AG, Chaniad P, Plirat W, Phuwajaroanpong A, Juengw… · 2026-09-04
open access unreviewed -
9
Endodontic potential of eugenol against <i>Enterococcus faecalis</i>: Antibacterial, antibiofilm, and network pharmacology insights.
Kannan KP, Smiline Girija AS. · 2026-08-31
open access unreviewed -
10
Dietary folic acid coordinates growth and lipid metabolism through gut microbial and one-carbon networks in juvenile mud crab (<i>Scylla paramamosain</i>).
Tang Z, Deng Y, Xie S, Zhan W, Peng H, Tian Y, Jin M, Xu T, Cui X, Li X, Sun P, Zhou Q. · 2026-07-07
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.