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unreviewed

Cytosolic uroporphyrinogen decarboxylase (UROD)

1 reactions · 1 pathways

Clinical / pharmacological. Porphyria cutanea tarda: photosensitive blistering, tea-coloured urine (commonest porphyria)

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 5 Irreversible

Uroporphyrinogen III → coproporphyrinogen III + 4 CO₂

Converts Uroporphyrinogen III into Coproporphyrinogen III CO2

› Notes

Cytosolic uroporphyrinogen decarboxylase (UROD) decarboxylates the four acetate side chains to methyl groups. No ATP or redox cofactor is required; this is an essentially irreversible decarboxylation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Phytoacoustics: sound perception, mechanosensing, and biological responses to sound in plants.

    Mos M, Kassner ZE, Robson PRH. · 2026-07-30

    open access unreviewed
  2. 2
    Discovery of ALA-hydroxypyridinone hybrids: novel strategies for photodynamic therapy against superficial tumours.

    Jiang X, Feng M, Niu X, Wang S, Sun Y, Chen W, Bai R. · 2026-07-08

    open access unreviewed
  3. 3
    Directed evolution of heme biosynthetic enzymes enabled by a growth-coupled heme biosensor in <i>Corynebacterium glutamicum</i>.

    Mou F, Li D, Wang H, Li J, Chen T, Wang Z. · 2026-05-25

    cited 1× open access unreviewed
  4. 4
    Novel bacterium <i>Enterocloster</i> sp. M3 promotes colorectal tumorigenesis via the production of the carcinogen styrene.

    Zeng Y, Huang Y, Ye S, Lau EYT, Chiu MC, Fenske L, Sun Y, Jiang L, Chen J, Huang Y, Zhou T, Lu J, Zhou J, Zhe… · 2026-02-16

    open access unreviewed
  5. 5
    Validation of next‑generation sequencing‑derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma.

    Zezulinski D, Hoteit MA, Kaplan DE, Zhan T, Doria C, Block TM, Sayeed A. · 2026-09-18

    open access unreviewed
  6. 6
    Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.

    Wang Y, Yang Y. · 2026-08-01

    unreviewed
  7. 7
    Integrated Proteomic Screening Reveals Heme Enzyme Depletion Induces Cyst-like Vacuole Formation in <i>Toxoplasma gondii</i>.

    Zhao Y, Wang Y, Yang R, Zhao A, Zhang Z, Qi M, Dong H. · 2026-09-13

    open access unreviewed
  8. 8
    Endogenous Biomarkers to Evaluate Transporter-Mediated Drug-Drug Interactions: Current Evidence, Impact on Clinical Pharmacology Strategy, Remaining Gaps, and Future Directions.

    Russell LE, Huang F, Cheung KWK, Varma MVS, Panduga V. · 2026-09-01

    unreviewed
  9. 9
    A Tarui Disease Phenotype with Compensated Hemolysis and a Homozygous <i>PFKM</i> Variant of Uncertain Significance Mimicking Chronic Myelomonocytic Leukemia.

    Neculcea AC, Aanicai R, Massoto B, Nistor RI, Fierbințeanu-Braticevici C, Mambet C, Mititelu A, Neagu AM, Par… · 2026-09-07

    open access unreviewed
  10. 10
    Milestones in the Elucidation of Heme Biosynthesis.

    Dailey HA. · 2026-09-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.