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unreviewed

Cytosolic uroporphyrinogen decarboxylase (UROD)

1 reactions · 1 pathways

Clinical / pharmacological. Porphyria cutanea tarda: photosensitive blistering, tea-coloured urine (commonest porphyria)

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 5 Irreversible

Uroporphyrinogen III → coproporphyrinogen III + 4 CO₂

Converts Uroporphyrinogen III into Coproporphyrinogen III CO2

› Notes

Cytosolic uroporphyrinogen decarboxylase (UROD) decarboxylates the four acetate side chains to methyl groups. No ATP or redox cofactor is required; this is an essentially irreversible decarboxylation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Novel bacterium <i>Enterocloster</i> sp. M3 promotes colorectal tumorigenesis via the production of the carcinogen styrene.

    Zeng Y, Huang Y, Ye S, Lau EYT, Chiu MC, Fenske L, Sun Y, Jiang L, Chen J, Huang Y, Zhou T, Lu J, Zhou J, Zhe… · 2026-02-16

    open access unreviewed
  2. 2
    Hepatoerythropoietic porphyria in a 2-year-old child: Clinical features and effects of treatment.

    Bensaber N, Tran B, Rebeiz L, Wang C, Tortorelli S, Yalom LK, Trinidad J, Wiltsie L, Kerkar N, Moghe A, Ander… · 2026-08-08

    unreviewed
  3. 3
    Structural and functional insights into aromatic amino acid decarboxylase deficiency variants producing an α-synuclein-targeting L-Dopa-pyridoxal 5'-phosphate cyclic adduct.

    Trolese P, Bisello G, Carmona CAC, Spagnoli G, Benetollo A, Sandonà D, Acquasaliente L, de Laureto PP, Bertol… · 2026-08-07

    unreviewed
  4. 4
    Updates to gene-disease classifications and inheritance patterns for porphyrias.

    Reeves EB, Hankey W, Clair PS, Goldstein JL, Wilke MVMB, Feigenbaum A, Hung C, Spector E, Craigen WJ. · 2026-04-30

    unreviewed
  5. 5
    5-ALA in Oncology: Current Clinical Applications, Biological Limitations, and Emerging Translational Strategies

    Inglot J, Bartusik-Aebisher D, Myśliwiec A, Dynarowicz K, Paul A, Xavierselvan M, Aebisher D. · 2026-06-01

    open access unreviewed
  6. 6
    Genome Assembly and Annotation for the Okinawan Green Marine Spoon Worm Bonellia viridis (Polychaeta: Bonelliidae)

    Bailey E, Soghigian J, Lorenzen M, Zhang R, Taniguchi M, Lindsey J, Wiegmann B, Jin X. · 2026-06-01

    open access unreviewed
  7. 7
    Homozygous variegate porphyria: Two cases misdiagnosed as erythropoietic protoporphyria.

    Wang C, Bensaber N, Rebeiz L, Tran B, Tortorelli S, Kyle K, Yalom LK, Moghe A, Anderson KE, Leaf RK, Yeung AK. · 2026-06-07

    open access unreviewed
  8. 8
    Mechanisms underlying green flower formation.

    Li X, Hong C, Li H, Hou S, Sun Q, Zang Y, Sun G, Huang Z, Gao H. · 2026-03-03

    open access unreviewed
  9. 9
    Glycine: The missing link between carbohydrate and xenobiotic metabolism in the maturing human hepatocyte.

    Pozo Garcia V, Çobanoğlu TS, Riga K, Sharma S, Jennings P, Vos JC, Moco S. · 2026-05-28

    open access unreviewed
  10. 10
    Environmental Concentrations of Herbicide Prometryn Increase the Susceptibility of Reef-Building Corals to Nitrate Stress.

    Li Q, Zhou Y, Kang W, Tang X, Hu B, Tang Z, Wu F, Downs CA, Zhao H. · 2026-06-03

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.