Cytosolic uroporphyrinogen decarboxylase (UROD)
Clinical / pharmacological. Porphyria cutanea tarda: photosensitive blistering, tea-coloured urine (commonest porphyria)
What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
Uroporphyrinogen III → coproporphyrinogen III + 4 CO₂
Converts Uroporphyrinogen III into Coproporphyrinogen III CO2
› Notes
Cytosolic uroporphyrinogen decarboxylase (UROD) decarboxylates the four acetate side chains to methyl groups. No ATP or redox cofactor is required; this is an essentially irreversible decarboxylation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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