Cytosolic malate dehydrogenase (MDH1)
Cofactors used
What it does, reaction by reaction
Malate-Aspartate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Cytosolic oxaloacetate + NADH + H+ -> malate + NAD+
Converts Cytosolic oxaloacetate NADH H+ into Malate NAD+
› Notes
Captures cytosolic (glycolytic) reducing equivalents as malate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.
Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04
open access unreviewed -
2
Iterative evolution of <i>Saccharomyces cerevisiae</i> enhances recombinant protease secretion.
Liu X, Lian M, Zeng J, Zheng L, Zhao M, Huang M. · 2026-04-25
open access unreviewed -
3
Effects of SGLT2 inhibitor dapagliflozin on the heart of rats with long-standing Type 1 diabetes mellitus: Protein profile.
Rodrigues EA, Dionizio A, Rosa CM, Campos DHS, Damatto FC, Reyes DRA, Souza LM, Santos PP, Gatto M, Borim PA,… · 2026-06-27
unreviewed -
4
TFF1-mediated suppression of the TCA cycle promotes bone metastasis in triple-negative breast cancer.
Chen H, Xu Y, Liu Y, Tang Y, Qiu J, Lei L, Lin P, Chen Y, Wu X. · 2026-06-09
open access unreviewed -
5
Tepraloxydim metabolite exposure disrupts placental function revealed by single-cell sequencing and metabolomics.
Teng Y, Qi Z, Han J, Duan Z, Cheng D, Xia J, Wang A, Yang L, Li H, Zhang T. · 2026-06-01
unreviewed -
6
Genetic variants associated with reduced body size in indigenous chickens of Eritrea: A genome-wide association study.
Habteslasie HA, Perini F, Ngeno K, Colombi D, Lasagna E, Dessie T, Kahi A. · 2026-07-27
unreviewed -
7
Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.
Li X, Li Y, Zhang C, Wang Y, Chen Z, Zeng R, Cen Y, Yang L, Yin S, Xiong Y, Xiong X, Li J. · 2026-07-15
unreviewed -
8
Dynamic assembly of malate dehydrogenase-citrate synthase multienzyme complex in the mitochondria.
Omini J, Krassovskaya I, Dele-Osibanjo TA, Pedersen C, Obata T. · 2026-07-08
unreviewed -
9
Mapping sarcopenia's causal proteome reveals a leptin-driven inflammatory-mitochondrial axis for early prediction.
Sun J, Yan M, Jiang D, Yang C, Duan F, Luo J, Chen H, Zhang JZ, Lian Q. · 2026-07-06
unreviewed -
10
MDH1 K298 succinylation stabilizes redox homeostasis to protect against cardiac ferroptosis in ischemia-reperfusion injury.
Li H, Liu J, Ren J, Gong M, Zhang Y, Cheng M, Li Y, Wang H, Wang S, Li X, Lv S, Zhang Y, Fan S, Chen X, Yang … · 2026-07-06
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.