Cytosolic malate dehydrogenase (MDH1)
Cofactors used
What it does, reaction by reaction
Malate-Aspartate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Cytosolic oxaloacetate + NADH + H+ -> malate + NAD+
Converts Cytosolic oxaloacetate NADH H+ into Malate NAD+
› Notes
Captures cytosolic (glycolytic) reducing equivalents as malate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
2
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress.
Li T, Su T, Tang S, Cao K, Hua P, Gao J, Cui H, Jiang T. · 2026-01-30
open access unreviewed -
3
Circadian reprogramming of inflammation and metabolism in chronic kidney disease.
Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06
open access unreviewed -
4
SnRK1 in stress adaptation and growth regulation: Insights from <i>Arabidopsis</i> to crops.
Zhong X, Zhang L, Han C, Bai M. · 2026-07-20
open access unreviewed -
5
Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.
Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04
open access unreviewed -
6
Iterative evolution of <i>Saccharomyces cerevisiae</i> enhances recombinant protease secretion.
Liu X, Lian M, Zeng J, Zheng L, Zhao M, Huang M. · 2026-04-25
open access unreviewed -
7
Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.
Li X, Li Y, Zhang C, Wang Y, Chen Z, Zeng R, Cen Y, Yang L, Yin S, Xiong Y, Xiong X, Li J. · 2026-07-15
unreviewed -
8
Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in <i>GNAS</i> (Gα<sub>s</sub>) mutant pancreas cancer.
Hagedorn GA, Spieser JC, Hirai N, Sato Y, Valentine J, Jiang H, Wang W, Czyzyk-Krzeska MF, Patra KC. · 2026-09-30
open access unreviewed -
9
Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC.
Wang Q, Xin Y, Zokaei E, Zeng L, Piecoro D, Chen M, Zhang Y, Yang KS, Wang C, Liu X, Yang HS. · 2026-08-26
open access unreviewed -
10
Multiomics profiling of bone in the Dpp3-deficient mice unveils altered protein and lipid composition.
Bevacqua E, Violi F, Granata V, Bedin F, Santillo M, Menale C, Mazziotti G, Sobacchi C. · 2026-08-03
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.