Cytosolic malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Malate + NAD+ ↔ oxaloacetate + NADH + H+
Converts Malate NAD+ into Oxaloacetate NADH H+
› Notes
Cytosolic malate dehydrogenase regenerates oxaloacetate and produces cytosolic NADH. The malate transport step itself is carrier-mediated rather than enzymatic; the two dehydrogenase reactions constitute the redox shuttle.
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Oxaloacetate + NADH + H+ → malate + NAD+
Converts Oxaloacetate NADH H+ into Malate NAD+
› Notes
Cytosolic malate dehydrogenase reduces oxaloacetate, using NADH. Malate may return to mitochondria or be used to generate NADPH.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
2
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress.
Li T, Su T, Tang S, Cao K, Hua P, Gao J, Cui H, Jiang T. · 2026-01-30
open access unreviewed -
3
Advancing our understanding of photosynthesis: discoveries and insights from aquatic plants.
Kazmi A, Li G, Yang J, Zhao X, Islam MF, Li X, Kimura S, Hou H. · 2026-06-29
open access unreviewed -
4
MdWRKY125 bridges cold condition and fruit flavor by activating the sucrose synthase gene <i>MdSUS3</i> in apple.
Zhuang YY, Du LD, Wei MM, Zhang WJ, Wang HC, Zhao TT, Hu DG. · 2026-08-06
open access unreviewed -
5
Circadian reprogramming of inflammation and metabolism in chronic kidney disease.
Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06
open access unreviewed -
6
SnRK1 in stress adaptation and growth regulation: Insights from <i>Arabidopsis</i> to crops.
Zhong X, Zhang L, Han C, Bai M. · 2026-07-20
open access unreviewed -
7
Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.
Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04
open access unreviewed -
8
Iterative evolution of <i>Saccharomyces cerevisiae</i> enhances recombinant protease secretion.
Liu X, Lian M, Zeng J, Zheng L, Zhao M, Huang M. · 2026-04-25
open access unreviewed -
9
Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.
Li X, Li Y, Zhang C, Wang Y, Chen Z, Zeng R, Cen Y, Yang L, Yin S, Xiong Y, Xiong X, Li J. · 2026-07-15
unreviewed -
10
Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in <i>GNAS</i> (Gα<sub>s</sub>) mutant pancreas cancer.
Hagedorn GA, Spieser JC, Hirai N, Sato Y, Valentine J, Jiang H, Wang W, Czyzyk-Krzeska MF, Patra KC. · 2026-09-30
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.