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unreviewed

Cytosolic malate dehydrogenase

2 reactions · 2 pathways

Cofactors used

NAD+ · B3 (Niacin) NADH · B3 (Niacin)

What it does, reaction by reaction

2 reactions

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 3 Reversible

Malate + NAD+ ↔ oxaloacetate + NADH + H+

Converts Malate NAD+ into Oxaloacetate NADH H+

› Notes

Cytosolic malate dehydrogenase regenerates oxaloacetate and produces cytosolic NADH. The malate transport step itself is carrier-mediated rather than enzymatic; the two dehydrogenase reactions constitute the redox shuttle.

Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol

step 3 Irreversible/directional

Oxaloacetate + NADH + H+ → malate + NAD+

Converts Oxaloacetate NADH H+ into Malate NAD+

› Notes

Cytosolic malate dehydrogenase reduces oxaloacetate, using NADH. Malate may return to mitochondria or be used to generate NADPH.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.

    Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04

    open access unreviewed
  2. 2
    Iterative evolution of <i>Saccharomyces cerevisiae</i> enhances recombinant protease secretion.

    Liu X, Lian M, Zeng J, Zheng L, Zhao M, Huang M. · 2026-04-25

    open access unreviewed
  3. 3
    Effects of SGLT2 inhibitor dapagliflozin on the heart of rats with long-standing Type 1 diabetes mellitus: Protein profile.

    Rodrigues EA, Dionizio A, Rosa CM, Campos DHS, Damatto FC, Reyes DRA, Souza LM, Santos PP, Gatto M, Borim PA,… · 2026-06-27

    unreviewed
  4. 4
    TFF1-mediated suppression of the TCA cycle promotes bone metastasis in triple-negative breast cancer.

    Chen H, Xu Y, Liu Y, Tang Y, Qiu J, Lei L, Lin P, Chen Y, Wu X. · 2026-06-09

    open access unreviewed
  5. 5
    Tepraloxydim metabolite exposure disrupts placental function revealed by single-cell sequencing and metabolomics.

    Teng Y, Qi Z, Han J, Duan Z, Cheng D, Xia J, Wang A, Yang L, Li H, Zhang T. · 2026-06-01

    unreviewed
  6. 6
    Genetic variants associated with reduced body size in indigenous chickens of Eritrea: A genome-wide association study.

    Habteslasie HA, Perini F, Ngeno K, Colombi D, Lasagna E, Dessie T, Kahi A. · 2026-07-27

    unreviewed
  7. 7
    Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.

    Li X, Li Y, Zhang C, Wang Y, Chen Z, Zeng R, Cen Y, Yang L, Yin S, Xiong Y, Xiong X, Li J. · 2026-07-15

    unreviewed
  8. 8
    Secondary structure characterization of thermal adaptation in cytosolic malate dehydrogenase (cMDH) from three intertidal snails.

    Liao ML, Zhang XL, Dong YW. · 2026-07-15

    unreviewed
  9. 9
    Dynamic assembly of malate dehydrogenase-citrate synthase multienzyme complex in the mitochondria.

    Omini J, Krassovskaya I, Dele-Osibanjo TA, Pedersen C, Obata T. · 2026-07-08

    unreviewed
  10. 10
    Mapping sarcopenia's causal proteome reveals a leptin-driven inflammatory-mitochondrial axis for early prediction.

    Sun J, Yan M, Jiang D, Yang C, Duan F, Luo J, Chen H, Zhang JZ, Lian Q. · 2026-07-06

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.