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unreviewed

Cytosolic argininosuccinate synthetase (ASS1)

1 reactions · 1 pathways

Cofactors used

ATP PPi

Clinical / pharmacological. Citrullinaemia type I

What it does, reaction by reaction

1 reactions

Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol

step 3 Irreversible

Citrulline + L-aspartate + ATP → argininosuccinate + AMP + PPᵢ

Converts Citrulline Aspartate ATP into Argininosuccinate AMP PPi

› Notes

Cytosolic argininosuccinate synthetase (ASS1) activates citrulline and adds aspartate. MgATP is cleaved to AMP + PPᵢ, making this an essentially irreversible step that consumes two additional high-energy phosphate equivalents.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.

    Szurek EA, Ngo VL, Abo H, Cebula A, Chassaing B, Howard RA, Hart M, Hori S, Weaver CT, Gewirtz AT, Ignatowicz… · 2026-05-24

    open access unreviewed
  2. 2
    Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats.

    Dos Santos IF, Salgado CM, Carregari VC, Dos Santos RW, de Souza DM, Viana LR, Gomes-Marcondes MCC. · 2026-05-14

    open access unreviewed
  3. 3
    Arginine deprivation induces prolonged autophagy activation and ROS-dependent cell death in glioblastoma multiforme.

    Abdelkhalek M, El-Jawhari Y, Shaheen M, Saad R, Sarieddine M, El-Husseini N, El-Sibai M, Abi-Habib RJ. · 2026-05-07

    open access unreviewed
  4. 4
    The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.

    Pu S, Yan J, Wu T. · 2026-03-18

    open access unreviewed
  5. 5
    A silk fibroin-based nanomodulator reshapes periodontal bone immunity by flipping the metabolic switch in macrophages to promote periodontal tissue regeneration.

    Wang H, Ma Y, Song Y, Huang Y, Ma X, Hu Y, Zhou P, Chen Y, Cai R, Xu X, Tao G. · 2026-05-22

    unreviewed
  6. 6
    Multi-omics analysis of arginine metabolism in ovarian cancer: A prognostic signature and GTF2F2-driven stromal remodeling.

    Zhang D, Sheng J, Hu Y, Wang J, Sun Y, Zhou Y, Zhu X, Teng Y. · 2026-07-13

    unreviewed
  7. 7
    Mechanism of Jianpi Qinghua granule in ameliorating metabolic dysfunction-associated fatty liver disease by targeting the DNMT-urea cycle axis.

    Xiao Y, Wu H, Ju W, Xu J, Chen C, Abuduhelili B, Cai M, Jin S, Yin Q, Tian J, Lu H, Han X. · 2026-05-08

    unreviewed
  8. 8
    Spatiotemporally reprogrammed L-arginine metabolic nanoregulator potentiates immunotherapy.

    Cheng Q, Shi X, Qin Q, Chen Y, Wang J, Wang L, Wang Z. · 2026-04-11

    open access unreviewed
  9. 9
    Integrated miRNA-mRNA profiling reveals candidate regulatory relationships associated with high-fat diet-induced muscle lipid deposition in black seabream (Acanthopagrus schlegelii).

    Ma C, Zhao W, Bao Y, Yang Q, Wu L, Zhu T, Sun P, Zhou Q, Jin M. · 2026-08-05

    unreviewed
  10. 10
    A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis.

    Pan H, Zhu H, Huang S, Chen L, Liu C, Huang Y, Li C, Yao Q, Gao Q, Ding R, Yan F, Ye F, Wu Z, Niu X, Li X, Xi… · 2026-08-05

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.