What it does, reaction by reaction
Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol
Citrulline + L-aspartate + ATP → argininosuccinate + AMP + PPᵢ
Converts Citrulline Aspartate ATP into Argininosuccinate AMP PPi
› Notes
Cytosolic argininosuccinate synthetase (ASS1) activates citrulline and adds aspartate. MgATP is cleaved to AMP + PPᵢ, making this an essentially irreversible step that consumes two additional high-energy phosphate equivalents.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Terpene synthases screening in agarwood tree <i>Aquilaria yunnanensis</i> leads to the discovery of agarospirol.
Wen S, Cheng W, Li Y, Er L, Wu M, Deng Z, Lu L, Liu T. · 2026-06-17
open access unreviewed -
2
Integrated miRNA-mRNA profiling reveals candidate regulatory relationships associated with high-fat diet-induced muscle lipid deposition in black seabream (Acanthopagrus schlegelii).
Ma C, Zhao W, Bao Y, Yang Q, Wu L, Zhu T, Sun P, Zhou Q, Jin M. · 2026-08-05
unreviewed -
3
Injectable microsphere-based delivery strategies for stem cells and their derivatives in tissue regeneration.
Liang R, Chen J, Huang J, Fu P, Shi Z, Yue Y, Wang H, Lun H, Lin Q, Cao F, Zeng H, Zhang X, Lin J. · 2026-07-10
open access unreviewed -
4
Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.
Szurek EA, Ngo VL, Abo H, Cebula A, Chassaing B, Howard RA, Hart M, Hori S, Weaver CT, Gewirtz AT, Ignatowicz… · 2026-05-24
cited 1× open access unreviewed -
5
Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats.
Dos Santos IF, Salgado CM, Carregari VC, Dos Santos RW, de Souza DM, Viana LR, Gomes-Marcondes MCC. · 2026-05-14
open access unreviewed -
6
Arginine deprivation induces prolonged autophagy activation and ROS-dependent cell death in glioblastoma multiforme.
Abdelkhalek M, El-Jawhari Y, Shaheen M, Saad R, Sarieddine M, El-Husseini N, El-Sibai M, Abi-Habib RJ. · 2026-05-07
open access unreviewed -
7
The role of mesencephalic astrocyte-derived neurotrophic factor in digestive diseases.
Pu S, Yan J, Wu T. · 2026-03-18
open access unreviewed -
8
Dual Urea Cycle Dysfunction Caused by Coexisting Argininosuccinic Aciduria and Citrin Deficiency: Clinical, Biochemical, and Molecular Insights From an Exceptional Case.
Zribi M, Bhouri M, Khatrouch S, Boudabous H, Häberle J, Abdelmoula MS, Chehida AB. · 2026-10-04
open access unreviewed -
9
Essential Oral Single Nutritional Therapy Products for Inherited Metabolic Diseases: Evidence and Consensus Assessment Using a Modified Delphi Method.
Stolwijk NN, Penninx BMF, Bosch AM, Langeveld M, Salomons GS, Hollak CEM, Essential Nutritional Therapy Produ… · 2026-11-01
open access unreviewed -
10
Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review).
Dong X, Hou Y, Shao J, Zhu H, Liu J. · 2026-09-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.