unreviewed

Cytosolic argininosuccinate synthetase (ASS1)

1 reactions · 1 pathways

Cofactors used

ATP PPi

Clinical / pharmacological. Citrullinaemia type I

What it does, reaction by reaction

1 reactions

Urea Cycle Amino Acid & Nitrogen Metabolism · Mitochondrial matrix + cytosol

step 3 Irreversible

Citrulline + L-aspartate + ATP → argininosuccinate + AMP + PPᵢ

Converts Citrulline Aspartate ATP into Argininosuccinate AMP PPi

› Notes

Cytosolic argininosuccinate synthetase (ASS1) activates citrulline and adds aspartate. MgATP is cleaved to AMP + PPᵢ, making this an essentially irreversible step that consumes two additional high-energy phosphate equivalents.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Load 10 most recent

Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.

Europe PMC · ten most recent, newest first