What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
Coproporphyrinogen III + O₂ → protoporphyrinogen IX + 2 CO₂
Converts Coproporphyrinogen III O2 into Protoporphyrinogen IX CO2
› Notes
Mitochondrial intermembrane-space-facing coproporphyrinogen oxidase (CPOX) oxidatively decarboxylates two propionate side chains to vinyl groups. Molecular oxygen is required, and the product re-enters the mitochondrial compartment for final steps.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
ALR couples IMS redox and heme biosynthesis beyond the disulfide relay.
Racho J, Stobbe D, Jirschitzka J, Croon M, Petrungaro C, Ali M, Wernet D, Habich M, Gawellek NS, Strippel J, … · 2026-07-17
unreviewed -
2
Tolerability of hormonal treatments in acute hepatic porphyria patients.
Arandjelovic A, Ross C, Ross G. · 2026-07-11
unreviewed -
3
Understanding the Clinical Spectrum of the Cutaneous and Acute Hepatic Porphyrias.
Vu TN, Talasila S, Jeha GM, Nadir U, Mohammad TF, Lim HW, Abraham I, Grove D, Tolkachjov SN. · 2026-05-29
unreviewed -
4
Updates to gene-disease classifications and inheritance patterns for porphyrias.
Reeves EB, Hankey W, Clair PS, Goldstein JL, Wilke MVMB, Feigenbaum A, Hung C, Spector E, Craigen WJ. · 2026-04-30
unreviewed -
5
5-ALA in Oncology: Current Clinical Applications, Biological Limitations, and Emerging Translational Strategies
Inglot J, Bartusik-Aebisher D, Myśliwiec A, Dynarowicz K, Paul A, Xavierselvan M, Aebisher D. · 2026-06-01
open access unreviewed -
6
Non-invasive quantitative assessment of kidney injury using near-infrared autofluorescence imaging.
Matsumoto A, Matsui I, Fushiki H, Kusunoki Y, Tamai N, Okushima H, Imai A, Shimada M, Harimoto T, Kato T, Hat… · 2026-06-18
unreviewed -
7
Glycine: The missing link between carbohydrate and xenobiotic metabolism in the maturing human hepatocyte.
Pozo Garcia V, Çobanoğlu TS, Riga K, Sharma S, Jennings P, Vos JC, Moco S. · 2026-05-28
open access unreviewed -
8
Is heme metabolism a promising drug target in Toxoplasma gondii?
Dou Z. · 2026-06-02
open access unreviewed -
9
Somatic mosaicism in the δ-aminolevulinate dehydratase gene causing late-onset porphyria with erythroid-driven pathogenesis.
Vizerov T, Demina N, Ponomarev R, Lukina E, Pshenichnikova O, Selivanova D, Tabakov V, Ryzhkova O. · 2026-05-14
open access unreviewed -
10
Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian Population.
Buianova AA, Cheranev VV, Shmitko AO, Vasiliadis IA, Samitova AF, Suchalko ON, Repinskaia ZA, Kuznetsov MI, B… · 2026-05-28
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.