What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
Coproporphyrinogen III + O₂ → protoporphyrinogen IX + 2 CO₂
Converts Coproporphyrinogen III O2 into Protoporphyrinogen IX CO2
› Notes
Mitochondrial intermembrane-space-facing coproporphyrinogen oxidase (CPOX) oxidatively decarboxylates two propionate side chains to vinyl groups. Molecular oxygen is required, and the product re-enters the mitochondrial compartment for final steps.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A transferrin receptor-targeted liposome for iron metabolism regulation-augmented photodynamic therapy in glioblastoma.
Wen R, He G, Wan Y, Guo X, Xiong S, Wu Y, Wei Y, Li D, Lin J, Huang P. · 2026-09-16
open access unreviewed -
2
Discovery of ALA-hydroxypyridinone hybrids: novel strategies for photodynamic therapy against superficial tumours.
Jiang X, Feng M, Niu X, Wang S, Sun Y, Chen W, Bai R. · 2026-07-08
open access unreviewed -
3
[Transition and transfer from pediatrics to adult medicine].
Obermayr V, Pichler I, Appelt D, Baumann M, Binder E, Geiger R, Kapelari K, Müller T, Rabensteiner E, Sailer-… · 2026-03-18
open access unreviewed -
4
Investigation of Fatty Acid Metabolism-Associated Molecular CPOX and the Underlying Mechanism in Follicular Lymphoma.
He J, Wang F, Shen C, Zhang K. · 2026-03-11
unreviewed -
5
Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance training-induced hypertrophy.
Moesgaard L, Moreno-Justicia R, Schmalbruch J, Jessen S, Stocks B, Andersen NR, Nielsen JJ, Yonamine CY, Tree… · 2026-09-02
open access unreviewed -
6
Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways.
Yuan S, Clark MG, Shakt G, Levin MG, Hartmann K, Judy R, Dinatale T, Voorhees A, Lynch JA, Pyarajan S, Levy D… · 2026-09-29
unreviewed -
7
Magnetically Guided Macrophage Immunobots Coordinate Iron-Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy.
Zeng X, Zhang Y, Wu C, Duan Q, Fan M, Wang K, Cai S, Yasa IC. · 2026-09-27
open access unreviewed -
8
Integrated Multi-Omic Analyses Reveal Gender-Specific Molecular Mechanisms Regulating Growth and Muscle Development in Zhongshan Partridge Ducks.
Ouyang T, Chao X, Yin Y, Ji C, Ma X, He Y, Cui T, Zhong H, Wu Z, Luo Q. · 2026-09-14
open access unreviewed -
9
Endogenous Biomarkers to Evaluate Transporter-Mediated Drug-Drug Interactions: Current Evidence, Impact on Clinical Pharmacology Strategy, Remaining Gaps, and Future Directions.
Russell LE, Huang F, Cheung KWK, Varma MVS, Panduga V. · 2026-09-01
unreviewed -
10
A Tarui Disease Phenotype with Compensated Hemolysis and a Homozygous <i>PFKM</i> Variant of Uncertain Significance Mimicking Chronic Myelomonocytic Leukemia.
Neculcea AC, Aanicai R, Massoto B, Nistor RI, Fierbințeanu-Braticevici C, Mambet C, Mititelu A, Neagu AM, Par… · 2026-09-07
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.